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Blood, 1 September 2006, Vol. 108, No. 5, pp. 1441-1450.
Prepublished online as a Blood First Edition Paper on April 11, 2006; DOI 10.1182/blood-2006-02-005363.
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REVIEW ARTICLES
Cell-surface association between matrix metalloproteinases and integrins: role of the complexes in leukocyte migration and cancer progression
Michael Stefanidakis, and
Erkki Koivunen
From the Department of Biological and Environmental Sciences, University of Helsinki, Finland.
Leukocyte motility is known to be dependent on both  2-integrins and matrix metalloproteinases MMP-2/-9 or gelatinases, which mediate leukocyte adhesion and the proteolysis needed for invasion, respectively. Gelatinases not only play an important role in cell migration, tissue remodeling, and angiogenesis during development, but are also involved in the progression and invasiveness of many cancers, including leukemias. The concept that MMPs associate with integrins, as well as their importance in some physiologic and pathologic conditions, has been advanced previously but has not been examined on leukocytes. This review will examine mainly the function of the MMP-integrin complexes in normal leukocyte migration and the effect of integrin and broad-spectrum MMP inhibitors in tumor progression.
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