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Blood, 1 September 2006, Vol. 108, No. 5, pp. 1441-1450. Prepublished online as a Blood First Edition Paper on April 11, 2006; DOI 10.1182/blood-2006-02-005363. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2006-02-005363v1 108/5/1441    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Stefanidakis, M. Articles by Koivunen, E. Search for Related Content PubMed PubMed Citation Articles by Stefanidakis, M. Articles by Koivunen, E. Related Collections Hematopoiesis and Stem Cells Immunobiology Neoplasia Phagocytes Cell Adhesion and Motility Review Articles Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  REVIEW ARTICLES Cell-surface association between matrix metalloproteinases and integrins: role of the complexes in leukocyte migration and cancer progression Michael Stefanidakis, and Erkki Koivunen From the Department of Biological and Environmental Sciences, University of Helsinki, Finland. Leukocyte motility is known to be dependent on both 2-integrins and matrix metalloproteinases MMP-2/-9 or gelatinases, which mediate leukocyte adhesion and the proteolysis needed for invasion, respectively. Gelatinases not only play an important role in cell migration, tissue remodeling, and angiogenesis during development, but are also involved in the progression and invasiveness of many cancers, including leukemias. The concept that MMPs associate with integrins, as well as their importance in some physiologic and pathologic conditions, has been advanced previously but has not been examined on leukocytes. This review will examine mainly the function of the MMP-integrin complexes in normal leukocyte migration and the effect of integrin and broad-spectrum MMP inhibitors in tumor progression. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: T. Vaisar, S. Y. Kassim, I. G. Gomez, P. S. Green, S. Hargarten, P. J. Gough, W. C. Parks, C. L. Wilson, E. W. Raines, and J. W. Heinecke MMP-9 Sheds the {beta}2 Integrin Subunit (CD18) from Macrophages Mol. Cell. Proteomics, May 1, 2009; 8(5): 1044 - 1060. [Abstract] [Full Text] [PDF] S. Li, H. Wang, B. Peng, M. Zhang, D. Zhang, S. Hou, Y. Guo, and J. Ding Efalizumab binding to the LFA-1 {alpha}L I domain blocks ICAM-1 binding via steric hindrance PNAS, March 17, 2009; 106(11): 4349 - 4354. [Abstract] [Full Text] [PDF] J. Redondo-Munoz, E. Ugarte-Berzal, J. A. Garcia-Marco, M. H. del Cerro, P. E. Van den Steen, G. Opdenakker, M. J. Terol, and A. Garcia-Pardo {alpha}4{beta}1 integrin and 190-kDa CD44v constitute a cell surface docking complex for gelatinase B/MMP-9 in chronic leukemic but not in normal B cells Blood, July 1, 2008; 112(1): 169 - 178. [Abstract] [Full Text] [PDF] G. Jiang, T. Freywald, J. Webster, D. Kozan, R. Geyer, J. DeCoteau, A. Narendran, and A. Freywald In Human Leukemia Cells Ephrin-B-Induced Invasive Activity Is Supported by Lck and Is Associated with Reassembling of Lipid Raft Signaling Complexes Mol. Cancer Res., February 1, 2008; 6(2): 291 - 305. [Abstract] [Full Text] [PDF] S. Christian, R. Winkler, I. Helfrich, A. M. Boos, E. Besemfelder, D. Schadendorf, and H. G. Augustin Endosialin (Tem1) Is a Marker of Tumor-Associated Myofibroblasts and Tumor Vessel-Associated Mural Cells Am. J. Pathol., February 1, 2008; 172(2): 486 - 494. [Abstract] [Full Text] [PDF] N. Said, M. J. Socha, J. J. Olearczyk, A. A. Elmarakby, J. D. Imig, and K. Motamed Normalization of the Ovarian Cancer Microenvironment by SPARC Mol. Cancer Res., October 1, 2007; 5(10): 1015 - 1030. [Abstract] [Full Text] [PDF] M. Shimoda, G. Hashimoto, S. Mochizuki, E. Ikeda, N. Nagai, S. Ishida, and Y. Okada Binding of ADAM28 to P-selectin Glycoprotein Ligand-1 Enhances P-selectin-mediated Leukocyte Adhesion to Endothelial Cells J. Biol. Chem., August 31, 2007; 282(35): 25864 - 25874. [Abstract] [Full Text] [PDF] C. Ries, V. Egea, M. Karow, H. Kolb, M. Jochum, and P. Neth MMP-2, MT1-MMP, and TIMP-2 are essential for the invasive capacity of human mesenchymal stem cells: differential regulation by inflammatory cytokines Blood, May 1, 2007; 109(9): 4055 - 4063. [Abstract] [Full Text] [PDF] J. Redondo-Munoz, E. Escobar-Diaz, R. Samaniego, M. J. Terol, J. A. Garcia-Marco, and A. Garcia-Pardo MMP-9 in B-cell chronic lymphocytic leukemia is up-regulated by {alpha}4beta1 integrin or CXCR4 engagement via distinct signaling pathways, localizes to podosomes, and is involved in cell invasion and migration Blood, November 1, 2006; 108(9): 3143 - 3151. [Abstract] [Full Text] [PDF]

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