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Blood, 1 September 2006, Vol. 108, No. 5, pp. 1643-1651. Prepublished online as a Blood First Edition Paper on May 4, 2006; DOI 10.1182/blood-2006-02-006361. This Article Full Text Full Text (PDF) Supplemental Figures All Versions of this Article: blood-2006-02-006361v1 108/5/1643    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Moris, A. Articles by Schwartz, O. Search for Related Content PubMed PubMed Citation Articles by Moris, A. Articles by Schwartz, O. Related Collections Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Dendritic cells and HIV-specific CD4+ T cells: HIV antigen presentation, T-cell activation, and viral transfer Arnaud Moris, Anthony Pajot, Fabien Blanchet, Florence Guivel-Benhassine, Margarita Salcedo, and Olivier Schwartz From the Groupe Virus et Immunité, Unité de Recherche Associée (URA) Centre National de la Recherche Scientifique (CNRS) 1930, Paris; Unité d'Immunité Cellulaire Antivirale, Institut Pasteur, Paris; and IDM Research Laboratories, Institut des Cordeliers, Paris, France. Human immunodeficiency virus (HIV)-specific CD4+ lymphocytes are preferentially infected in HIV-positive individuals. To study this preferential infection, we have derived several HIV-specific (HS) CD4+ clones. We show that in dendritic cells (DCs), HIV virion capture led to major histocompatibility complex class-II (MHC-II)-restricted viral antigen presentation and to activation of HS cells. In contrast, neither cell-free virions nor infected lymphocytes activated HS cells. In DCs, the dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN/CD209), which internalizes virions, promoted MHC-II presentation of HIV antigens. Activation of HS cells by HIV-exposed DCs triggered an efficient viral spread in lymphocytes. CD4+ clones with irrelevant antigenic specificities were not activated by HIV-exposed DCs and poorly supported viral replication under this setting. Our results unravel the mechanisms of MHC-II-restricted HIV antigen presentation by DCs and describe how HIV gains access to the very cells designed by the immune system to counteract this pathogen. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. R. Almeida, D. Sauce, D. A. Price, L. Papagno, S. Y. Shin, A. Moris, M. Larsen, G. Pancino, D. C. Douek, B. Autran, et al. Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activity Blood, June 18, 2009; 113(25): 6351 - 6360. [Abstract] [Full Text] [PDF] J. B. Sacha, J. P. Giraldo-Vela, M. B. Buechler, M. A. Martins, N. J. Maness, C. Chung, L. T. Wallace, E. J. Leon, T. C. Friedrich, N. A. Wilson, et al. Gag- and Nef-specific CD4+ T cells recognize and inhibit SIV replication in infected macrophages early after infection PNAS, June 16, 2009; 106(24): 9791 - 9796. [Abstract] [Full Text] [PDF] B. Liu, A. M. Woltman, H. L. A. Janssen, and A. Boonstra Modulation of dendritic cell function by persistent viruses J. Leukoc. Biol., February 1, 2009; 85(2): 205 - 214. [Abstract] [Full Text] [PDF] A. A. Lambert, C. Gilbert, M. Richard, A. D. Beaulieu, and M. J. Tremblay The C-type lectin surface receptor DCIR acts as a new attachment factor for HIV-1 in dendritic cells and contributes to trans- and cis-infection pathways Blood, August 15, 2008; 112(4): 1299 - 1307. [Abstract] [Full Text] [PDF] I. Frank, H. Stossel, A. Gettie, S. G. Turville, J. W. Bess Jr., J. D. Lifson, I. Sivin, N. Romani, and M. Robbiani A Fusion Inhibitor Prevents Spread of Immunodeficiency Viruses, but Not Activation of Virus-Specific T Cells, by Dendritic Cells J. Virol., June 1, 2008; 82(11): 5329 - 5339. [Abstract] [Full Text] [PDF] J.-H. Wang, A. M. Janas, W. J. Olson, and L. Wu Functionally Distinct Transmission of Human Immunodeficiency Virus Type 1 Mediated by Immature and Mature Dendritic Cells J. Virol., September 1, 2007; 81(17): 8933 - 8943. [Abstract] [Full Text] [PDF] N. Izquierdo-Useros, J. Blanco, I. Erkizia, M. T. Fernandez-Figueras, F. E. Borras, M. Naranjo-Gomez, M. Bofill, L. Ruiz, B. Clotet, and J. Martinez-Picado Maturation of Blood-Derived Dendritic Cells Enhances Human Immunodeficiency Virus Type 1 Capture and Transmission J. Virol., July 15, 2007; 81(14): 7559 - 7570. [Abstract] [Full Text] [PDF] M. Pion, A. Granelli-Piperno, B. Mangeat, R. Stalder, R. Correa, R. M. Steinman, and V. Piguet APOBEC3G/3F mediates intrinsic resistance of monocyte-derived dendritic cells to HIV-1 infection J. Exp. Med., December 25, 2006; 203(13): 2887 - 2893. [Abstract] [Full Text] [PDF]

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