SEARCH:   Advanced

Blood, 1 September 2006, Vol. 108, No. 5, pp. 1661-1667. Prepublished online as a Blood First Edition Paper on May 9, 2006; DOI 10.1182/blood-2006-04-014563. This Article Full Text Full Text (PDF) Supplemental Table and Figures All Versions of this Article: blood-2006-04-014563v1 108/5/1661    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Vacca, A. Articles by Dammacco, F. Search for Related Content PubMed PubMed Citation Articles by Vacca, A. Articles by Dammacco, F. Related Collections Hemostasis, Thrombosis, and Vascular Biology Neoplasia Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  NEOPLASIA Loss of inhibitory semaphorin 3A (SEMA3A) autocrine loops in bone marrow endothelial cells of patients with multiple myeloma Angelo Vacca, Claudio Scavelli, Guido Serini, Giulia Di Pietro, Teresa Cirulli, Francesca Merchionne, Domenico Ribatti, Federico Bussolino, Diego Guidolin, Giovanna Piaggio, Andrea Bacigalupo, and Franco Dammacco From the Department of Internal Medicine and Clinical Oncology and the Department of Human Anatomy and Histology, University of Bari Medical School, Bari; the Department of Oncological Sciences and Division of Molecular Angiogenesis, Institute for Cancer Research and Treatment, University of Turin Medical School, Candiolo; the Department of Human Anatomy and Physiology, University of Padua Medical School, Padua; and the Department of Hemato-Oncology, S Martino Hospital, Genoa, Italy. Vascular endothelial growth factor165 (VEGF165) and semaphorin3A (SEMA3A) elicit pro- and antiangiogenic signals respectively in endothelial cells (ECs) by binding to their receptors VEGFR-2, neuropilin-1 (NRP1), and plexin-A1. Here we show that the VEGF165-driven angiogenic potential of multiple myeloma (MM) ECs is significantly higher than that of monoclonal gammopathy of undetermined significance (MGUS) ECs (MGECs) and human umbilical vein (HUV) ECs. This is probably due to a constitutive imbalance of endogenous VEGF165/SEMA3A ratio, which leans on VEGF165 in MMECs but on SEMA3A in MGECs and HUVECs. Exogenous VEGF165 induces SEMA3A expression in MGECs and HUVECs, but not in MMECs. Moreover, by counteracting VEGF165 activity as efficiently as an anti-VEGFR-2 antibody, exogenous SEMA3A restrains the over-angiogenic potential of MMECs. Our data indicate that loss of endothelial SEMA3A in favor of VEGF165 could be responsible for the angiogenic switch from MGUS to MM. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: R. Ria, K. Todoerti, S. Berardi, A. M. L. Coluccia, A. De Luisi, M. Mattioli, D. Ronchetti, F. Morabito, A. Guarini, M. T. Petrucci, et al. Gene Expression Profiling of Bone Marrow Endothelial Cells in Patients with Multiple Myeloma Clin. Cancer Res., September 1, 2009; 15(17): 5369 - 5378. [Abstract] [Full Text] [PDF] L. Capparuccia and L. Tamagnone Semaphorin signaling in cancer cells and in cells of the tumor microenvironment - two sides of a coin J. Cell Sci., June 1, 2009; 122(11): 1723 - 1736. [Abstract] [Full Text] [PDF] G. Serini, L. Napione, M. Arese, and F. Bussolino Besides adhesion: new perspectives of integrin functions in angiogenesis Cardiovasc Res, May 1, 2008; 78(2): 213 - 222. [Abstract] [Full Text] [PDF] R. Ria, C. Piccoli, T. Cirulli, F. Falzetti, G. Mangialardi, D. Guidolin, A. Tabilio, N. Di Renzo, A. Guarini, D. Ribatti, et al. Endothelial Differentiation of Hematopoietic Stem and Progenitor Cells from Patients with Multiple Myeloma Clin. Cancer Res., March 15, 2008; 14(6): 1678 - 1685. [Abstract] [Full Text] [PDF] C. Scavelli, G. Di Pietro, T. Cirulli, M. Coluccia, A. Boccarelli, T. Giannini, G. Mangialardi, R. Bertieri, A. M. L. Coluccia, D. Ribatti, et al. Zoledronic acid affects over-angiogenic phenotype of endothelial cells in patients with multiple myeloma Mol. Cancer Ther., December 1, 2007; 6(12): 3256 - 3262. [Abstract] [Full Text] [PDF] V. A. Potiron, G. Sharma, P. Nasarre, J. A. Clarhaut, H. G. Augustin, R. M. Gemmill, J. Roche, and H. A. Drabkin Semaphorin SEMA3F Affects Multiple Signaling Pathways in Lung Cancer Cells Cancer Res., September 15, 2007; 67(18): 8708 - 8715. [Abstract] [Full Text] [PDF] C. W. Vander Kooi, M. A. Jusino, B. Perman, D. B. Neau, H. D. Bellamy, and D. J. Leahy Structural basis for ligand and heparin binding to neuropilin B domains PNAS, April 10, 2007; 104(15): 6152 - 6157. [Abstract] [Full Text] [PDF]

	Copyright © 2006 by American Society of Hematology         Online ISSN: 1528-0020