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 Blood, 1 September 2006, Vol. 108, No. 5, pp. 1767-1769.
Prepublished online as a Blood First Edition Paper on April 27, 2006; DOI 10.1182/blood-2006-02-005645.

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TRANSPLANTATION
Brief report

Reproductive capability in dogs with canine leukocyte adhesion deficiency treated with nonmyeloablative conditioning prior to allogeneic hematopoietic stem cell transplantation

Tanya H. Burkholder, Lyn Colenda, Laura M. Tuschong, Matthew F. Starost, Thomas R. Bauer, Jr, and Dennis D. Hickstein

From the Division of Veterinary Resources, Office of Research Services, National Institutes of Health, Bethesda, MD; and the Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.

Nonmyeloablative conditioning regimens are increasingly replacing myeolablative conditioning prior to allogeneic hematopoietic stem cell transplantation (SCT). The recent advent of these conditioning regimens has limited the assessment of the long-term effects of this treatment, including analysis of reproductive function. To address the question of reproductive function after nonmyeloablative transplantation, we analyzed a cohort of young dogs with the genetic disease canine leukocyte adhesion deficiency that were treated with a nonmyeloablative dose of 200 cGy total body irradiation followed by matched-littermate SCT. Five males and 5 females entered puberty; all 5 males and 4 females subsequently sired or delivered litters following transplantation. We demonstrate that fertility is intact and dogs have uncomplicated parturitions following nonmyeloablative conditioning for SCT. These results are encouraging for children and adults of childbearing age who receive similar conditioning regimens prior to allogeneic transplantation.


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W. Qasim, M. Cavazzana-Calvo, E. G. Davies, J. Davis, M. Duval, G. Eames, N. Farinha, A. Filopovich, A. Fischer, W. Friedrich, et al.
Allogeneic Hematopoietic Stem-Cell Transplantation for Leukocyte Adhesion Deficiency
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