Blood online
Home About Blood Authors Subscriptions Permission Advertising Public Access contact us
 

 
Advanced
Current Issue
First Edition
Archives
Submit to Blood
Search
American Society of Hematology
Meeting Abstracts
Email Alerts
Blood, 1 October 2006, Vol. 108, No. 7, pp. 2190-2197.
Prepublished online as a Blood First Edition Paper on June 1, 2006; DOI 10.1182/blood-2005-12-010272.


This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
blood-2005-12-010272v1
108/7/2190    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Right arrow Rights and Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Xing, Z.
Right arrow Articles by Geiger, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Xing, Z.
Right arrow Articles by Geiger, H.
Related Collections
Right arrow Hematopoiesis and Stem Cells
Right arrow Cell Adhesion and Motility
Right arrow Stem Cells in Hematology
Social Bookmarking
 Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

arrow to previous article Previous Article  |  Table of Contents  |  Next Article next article arrow

HEMATOPOIESIS

Increased hematopoietic stem cell mobilization in aged mice

Zhenlan Xing, Marnie A. Ryan, Deidre Daria, Kalpana J. Nattamai, Gary Van Zant, Lei Wang, Yi Zheng, and Hartmut Geiger

From the Division of Experimental Hematology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH; and the Departments of Internal Medicine and Physiology, Markey Cancer Center, University of Kentucky, Lexington, KY.

Hematopoietic stem and progenitor cells (HSPCs) are located in the bone marrow in close association with a highly organized 3-dimensional structure formed by stroma cells, referred to as the niche. Mobilization of HSPCs from bone marrow to peripheral blood in response to granulocyte colony-stimulating factor (G-CSF) requires de-adhesion of HSPCs from the niche. The influence of aging of HSPCs on cell-stroma interactions has not been determined in detail. Using a mouse model of G-CSF–induced mobilization, we demonstrated that the ability to mobilize hematopoietic stem cells is approximately 5-fold greater in aged mice. Competitive mobilization experiments confirmed that enhanced mobilization ability was intrinsic to the stem cell. Enhanced mobilization efficiency of primitive hematopoietic cells from aged mice correlated with reduced adhesion of hematopoietic progenitor cells to stroma and with elevated levels of GTP-bound Cdc42. These results might indicate that stroma–stem cell interactions are dynamic over a lifetime and result in physiologically relevant changes in the biology of primitive hematopoietic cells with age.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
BloodHome page
S. Vasu, S. F. Leitman, J. F. Tisdale, M. M. Hsieh, R. W. Childs, A. J. Barrett, D. H. Fowler, M. R. Bishop, E. M. Kang, H. L. Malech, et al.
Donor demographic and laboratory predictors of allogeneic peripheral blood stem cell mobilization in an ethnically diverse population
Blood, September 1, 2008; 112(5): 2092 - 2100.
[Abstract] [Full Text] [PDF]


Home page
IOVSHome page
M. Thill, N. V. Strunnikova, M. J. Berna, N. Gordiyenko, K. Schmid, S. W. Cousins, D. J. S. Thompson, and K. G. Csaky
Late Outgrowth Endothelial Progenitor Cells in Patients with Age-Related Macular Degeneration
Invest. Ophthalmol. Vis. Sci., June 1, 2008; 49(6): 2696 - 2708.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
O. Krejci, M. Wunderlich, H. Geiger, F.-S. Chou, D. Schleimer, M. Jansen, P. R. Andreassen, and J. C. Mulloy
p53 signaling in response to increased DNA damage sensitizes AML1-ETO cells to stress-induced death
Blood, February 15, 2008; 111(4): 2190 - 2199.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
D. Daria, M.-D. Filippi, E. S. Knudsen, R. Faccio, Z. Li, T. Kalfa, and H. Geiger
The retinoblastoma tumor suppressor is a critical intrinsic regulator for hematopoietic stem and progenitor cells under stress
Blood, February 15, 2008; 111(4): 1894 - 1902.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
L. Wang, L. Yang, M. Debidda, D. Witte, and Y. Zheng
Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes
PNAS, January 23, 2007; 104(4): 1248 - 1253.
[Abstract] [Full Text] [PDF]



 click for free articles
home about blood authors subscriptions permissions advertising public access contact us
  Copyright © 2006 by American Society of Hematology         Online ISSN: 1528-0020