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Blood, 1 October 2006, Vol. 108, No. 7, pp. 2190-2197. Prepublished online as a Blood First Edition Paper on June 1, 2006; DOI 10.1182/blood-2005-12-010272. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2005-12-010272v1 108/7/2190    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Xing, Z. Articles by Geiger, H. Search for Related Content PubMed PubMed Citation Articles by Xing, Z. Articles by Geiger, H. Related Collections Hematopoiesis and Stem Cells Cell Adhesion and Motility Stem Cells in Hematology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMATOPOIESIS Increased hematopoietic stem cell mobilization in aged mice Zhenlan Xing, Marnie A. Ryan, Deidre Daria, Kalpana J. Nattamai, Gary Van Zant, Lei Wang, Yi Zheng, and Hartmut Geiger From the Division of Experimental Hematology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH; and the Departments of Internal Medicine and Physiology, Markey Cancer Center, University of Kentucky, Lexington, KY. Hematopoietic stem and progenitor cells (HSPCs) are located in the bone marrow in close association with a highly organized 3-dimensional structure formed by stroma cells, referred to as the niche. Mobilization of HSPCs from bone marrow to peripheral blood in response to granulocyte colony-stimulating factor (G-CSF) requires de-adhesion of HSPCs from the niche. The influence of aging of HSPCs on cell-stroma interactions has not been determined in detail. Using a mouse model of G-CSF–induced mobilization, we demonstrated that the ability to mobilize hematopoietic stem cells is approximately 5-fold greater in aged mice. Competitive mobilization experiments confirmed that enhanced mobilization ability was intrinsic to the stem cell. Enhanced mobilization efficiency of primitive hematopoietic cells from aged mice correlated with reduced adhesion of hematopoietic progenitor cells to stroma and with elevated levels of GTP-bound Cdc42. These results might indicate that stroma–stem cell interactions are dynamic over a lifetime and result in physiologically relevant changes in the biology of primitive hematopoietic cells with age. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. Jeong, Z.-H. Piao, M. S. Kim, S. H. Lee, S. Yun, H.-n. Sun, S. R. Yoon, J. W. Chung, T.-D. Kim, J. H. Jeon, et al. Thioredoxin-Interacting Protein Regulates Hematopoietic Stem Cell Quiescence and Mobilization under Stress Conditions J. Immunol., August 15, 2009; 183(4): 2495 - 2505. [Abstract] [Full Text] [PDF] A. Kohler, V. Schmithorst, M.-D. Filippi, M. A. Ryan, D. Daria, M. Gunzer, and H. Geiger Altered cellular dynamics and endosteal location of aged early hematopoietic progenitor cells revealed by time-lapse intravital imaging in long bones Blood, July 9, 2009; 114(2): 290 - 298. [Abstract] [Full Text] [PDF] J.-J. Lataillade, O. Pierre-Louis, H. C. Hasselbalch, G. Uzan, C. Jasmin, M.-C. Martyre, M.-C. Le Bousse-Kerdiles, and on behalf of the French INSERM and the European EU Does primary myelofibrosis involve a defective stem cell niche? 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