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Blood, 1 October 2006, Vol. 108, No. 7, pp. 2420-2427.
Prepublished online as a Blood First Edition Paper on June 13, 2006; DOI 10.1182/blood-2006-04-015933.
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PHAGOCYTES
Schistosoma mansoni infection in eosinophil lineage–ablated mice
Jonathan M. Swartz,
Kimberly D. Dyer,
Allen W. Cheever,
Thirumalai Ramalingam,
Lesley Pesnicak,
Joseph B. Domachowske,
James J. Lee,
Nancy A. Lee,
Paul S. Foster,
Thomas A. Wynn, and
Helene F. Rosenberg
From the Laboratory of Allergic Diseases, the Laboratory of Parasitic Diseases, and the Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD; the Department of Pediatrics, State University of New York (SUNY) Upstate Medical University, Syracuse, NY; the Mayo Clinic Arizona, Scottsdale, AZ; and the School of Biomedical Sciences, Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW, Australia.
We explore the controversial issue of the role of eosinophils in host defense against helminthic parasites using the established Schistosoma mansoni infection model in 2 novel mouse models of eosinophil lineage ablation ( dblGATA and TgPHIL). No eosinophils were detected in bone marrow of infected dblGATA or TgPHIL mice, despite the fact that serum IL-5 levels in these infected mice exceeded those in infected wild type by approximately 4-fold. Liver granulomata from infected dblGATA and TgPHIL mice were likewise depleted of eosinophils compared with those from their respective wild types. No eosinophil-dependent differences in granuloma number, size, or fibrosis were detected at weeks 8 or 12 of infection, and differential accumulation of mast cells was observed among the dblGATA mice only at week 12. Likewise, serum levels of liver transaminases, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) increased in all mice in response to S mansoni infection, with no eosinophil-dependent differences in hepatocellular damage observed. Finally, eosinophil ablation had no effect on worm burden or on egg deposition. Overall, our data indicate that eosinophil ablation has no impact on traditional measures of disease in the S mansoni infection model in mice. However, eosinophils may have unexplored immunomodulatory contributions to this disease process.
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