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Blood, 15 October 2006, Vol. 108, No. 8, pp. 2531-2539. Prepublished online as a Blood First Edition Paper on June 29, 2006; DOI 10.1182/blood-2006-05-024190. This Article Full Text Full Text (PDF) Supplemental Figure All Versions of this Article: blood-2006-05-024190v1 108/8/2531    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Liu, C. Articles by Takahama, Y. Search for Related Content PubMed PubMed Citation Articles by Liu, C. Articles by Takahama, Y. Related Collections Immunobiology Free Research Articles Chemokines, Cytokines, and Interleukins Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CHEMOKINES, CYTOKINES, AND INTERLEUKINS Coordination between CCR7- and CCR9-mediated chemokine signals in prevascular fetal thymus colonization Cunlan Liu, Fumi Saito, Zhijie Liu, Yu Lei, Shoji Uehara, Paul Love, Martin Lipp, Shunzo Kondo, Nancy Manley, and Yousuke Takahama From the Division of Experimental Immunology, Institute for Genome Research, University of Tokushima, Japan; the Department of Genetics, University of Georgia, Athens; the Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD; the Department of Molecular Tumorgenetics and Immunogenetics, Max-Delbrück Center (MDC) for Molecular Medicine, Berlin, Germany; and JEOL, Akishima, Tokyo, Japan. Thymus seeding by T-lymphoid progenitor cells is a prerequisite for T-cell development. However, molecules guiding thymus colonization and their roles before and after thymus vascularization are unclear. Here we show that mice doubly deficient for chemokine receptors CCR7 and CCR9 were defective specifically in fetal thymus colonization before, but not after, thymus vascularization. The defective prevascular fetal thymus colonization was followed by selective loss of the first wave of T-cell development generating epidermal V3+ T cells. Unexpectedly, CCL21, a CCR7 ligand, was expressed not by Foxn1-dependent thymic primordium but by Gcm2-dependent parathyroid primordium, whereas CCL25, a CCR9 ligand, was predominantly expressed by Foxn1-dependent thymic primordium, revealing the role of the adjacent parathyroid in guiding fetal thymus colonization. These results indicate coordination between Gcm2-dependent parathyroid and Foxn1-dependent thymic primordia in establishing CCL21/CCR7- and CCL25/CCR9-mediated chemokine guidance essential for prevascular fetal thymus colonization. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Thymus colonization: a shared responsibility Graham Anderson Blood 2006 108: 2497. [Full Text] [PDF] This article has been cited by other articles: E. Clave, M. Busson, C. Douay, R. Peffault de Latour, J. Berrou, C. Rabian, M. Carmagnat, V. Rocha, D. Charron, G. Socie, et al. Acute graft-versus-host disease transiently impairs thymic output in young patients after allogeneic hematopoietic stem cell transplantation Blood, June 18, 2009; 113(25): 6477 - 6484. [Abstract] [Full Text] [PDF] D. A. Sultana, S. Tomita, M. Hamada, Y. Iwanaga, Y. Kitahama, N. Van Khang, S. Hirai, I. Ohigashi, S. Nitta, T. Amagai, et al. 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[Abstract] [Full Text] [PDF] K. Kissa, E. Murayama, A. Zapata, A. Cortes, E. Perret, C. Machu, and P. Herbomel Live imaging of emerging hematopoietic stem cells and early thymus colonization Blood, February 1, 2008; 111(3): 1147 - 1156. [Abstract] [Full Text] [PDF] M. Svensson, J. Marsal, H. Uronen-Hansson, M. Cheng, W. Jenkinson, C. Cilio, S. E. W. Jacobsen, E. Sitnicka, G. Anderson, and W. W. Agace Involvement of CCR9 at multiple stages of adult T lymphopoiesis J. Leukoc. Biol., January 1, 2008; 83(1): 156 - 164. [Abstract] [Full Text] [PDF] E. M. Six, D. Bonhomme, M. Monteiro, K. Beldjord, M. Jurkowska, C. Cordier-Garcia, A. Garrigue, L. Dal Cortivo, B. Rocha, A. Fischer, et al. A human postnatal lymphoid progenitor capable of circulating and seeding the thymus J. Exp. Med., December 24, 2007; 204(13): 3085 - 3093. [Abstract] [Full Text] [PDF] J. Gui, X. Zhu, J. Dohkan, L. Cheng, P. F. Barnes, and D.-M. 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