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 Blood, 1 November 2006, Vol. 108, No. 9, pp. 2897-2905.
Prepublished online as a Blood First Edition Paper on July 20, 2006; DOI 10.1182/blood-2005-11-007237.

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CHEMOKINES, CYTOKINES, AND INTERLEUKINS

CD45RA on human CD8 T cells is sensitive to the time elapsed since the last antigenic stimulation

Javier Carrasco, Danièle Godelaine, Aline Van Pel, Thierry Boon, and Pierre van der Bruggen

From the Ludwig Institute for Cancer Research, Brussels, Belgium; and the Institute of Cellular Pathology, Cellular Genetics Unit, Université Catholique de Louvain, Brussels, Belgium.

The expression of CD45RA on CCR7– human CD8+ memory T cells is widely considered to be a marker of terminal differentiation. We studied the time course of CD45RA and CCR7 expression on human antitumoral cytotoxic T lymphocyte (CTL) clones and blood CD8+ T cells after antigenic stimulation. Our results indicate that CD45RA+CCR7– CD8+ T cells are resting memory cells that, upon antigenic stimulation and during the next 10 days, proliferate, lose CD45RA, and transiently acquire CCR7. In the absence of further antigenic stimulation, they progressively re-express CD45RA and become CD45RA+CCR7–. We conclude that the expression of CD45RA on these cells is indicative of the time elapsed since the last antigenic stimulation rather than the incapacity to proliferate or particularly high lytic potential. This concept leads to a reinterpretation of the significance of the presence of CD45RA+ CD8+ memory cells in patients affected by viral infections or by cancer.


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E. C. P. Waller, N. McKinney, R. Hicks, A. J. Carmichael, J. G. P. Sissons, and M. R. Wills
Differential costimulation through CD137 (4 1BB) restores proliferation of human virus-specific "effector memory" (CD28 CD45RAHI) CD8+ T cells
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