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Blood, 1 November 2006, Vol. 108, No. 9, pp. 2923-2927. Prepublished online as a Blood First Edition Paper on May 11, 2006; DOI 10.1182/blood-2006-01-011072. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2006-01-011072v1 108/9/2923    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Boyd, J. H. Articles by DeBaun, M. R. Search for Related Content PubMed PubMed Citation Articles by Boyd, J. H. Articles by DeBaun, M. R. Related Collections Clinical Trials and Observations Red Cells Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CLINICAL TRIALS AND OBSERVATIONS Asthma is associated with acute chest syndrome and pain in children with sickle cell anemia Jessica H. Boyd, Eric A. Macklin, Robert C. Strunk, and Michael R. DeBaun From the Department of Pediatrics, Division of Allergy and Pulmonary Medicine, and the Department of Pediatrics, Division of Genetics, Washington University School of Medicine, St Louis, MO; and New England Research Institutes, Watertown, MA. Pain and acute chest syndrome (ACS) episodes are 2 of the most common causes of hospitalization in children with sickle cell anemia (SCA). However, very few potentially modifiable risk factors for either condition have been identified. In this prospective infant cohort study, we tested the hypothesis that asthma is associated with an increased incidence rate of pain and ACS episodes. An infant cohort was composed of 291 African American children with hemoglobin SS enrolled in the Cooperative Study for Sickle Cell Disease before age 6 months and followed beyond age 5 years. Asthma was defined by a physician diagnosis, an acute asthma event, or use of prescription asthma medications. The incidence rates of ACS and painful episodes were compared for children with and without asthma. A clinical diagnosis of asthma was made in 17% of the cohort. Asthma was associated with more frequent ACS episodes (0.39 vs 0.20 events per patient year, P < .001) and painful episodes (1.39 vs 0.47 events per patient year, P < .001). In conclusion, in children with SCA, asthma is associated with an increased incidence of sickle cell disease–related morbidity, including ACS and painful episodes. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. H. Boyd, E. A. Macklin, R. C. Strunk, and M. R. DeBaun Asthma is associated with Increased mortality in individuals with sickle cell anemia Haematologica, August 1, 2007; 92(8): 1115 - 1118. [Abstract] [Full Text] [PDF] M. R. DeBaun and J. J. Field Limitations of Clinical Trials in Sickle Cell Disease: A Case Study of the Multi-center Study of Hydroxyurea (MSH) Trial and the Stroke Prevention (STOP) Trial Hematology, January 1, 2007; 2007(1): 482 - 488. [Abstract] [Full Text] [PDF]

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