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Blood, 1 November 2006, Vol. 108, No. 9, pp. 3094-3102.
Prepublished online as a Blood First Edition Paper on July 11, 2006; DOI 10.1182/blood-2006-04-016659.
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IMMUNOBIOLOGY
Presence of neutrophil-bearing antigen in lymphoid organs of immune mice
Belkys A. Maletto,
Andrea S. Ropolo,
Diego O. Alignani,
Miriam V. Liscovsky,
Romina P. Ranocchia,
Victor Gabriel Moron, and
María C. Pistoresi-Palencia
From the Departamento de Bioquímica Clínica, Centro de Investigaciones en Bioquímica Clínica e Inmunología—Consejo Nacional de Investigaciones Científicas y Técnicas (CIBICI CONICET), Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.
Neutrophils play a crucial early role during the innate response, but little is known about their possible contribution when an adaptive immune response is installed. A robust neutrophilia and a T helper 1 (Th1) immune response are present after immunization with Complete Freund Adjuvant (CFA). We show that when FITC-labeled OVA was injected into the footpad of OVA/CFA immunized mice, the main OVA-FITC+ cells recruited in draining popliteal lymph nodes (LNs) were neutrophils, with most of them arriving at the LN by means of lymphatic vessels. The development of this OVA-FITC+ neutrophil influx requires an immune response against OVA. The OVA-FITC+ neutrophils present in LNs displayed mainly intracellular TNF- , and their depletion resulted in an increase in the specific IL-5 levels. These data provide new evidence about the role played by neutrophils in vivo in adaptive immunity.
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