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Blood, 1 November 2006, Vol. 108, No. 9, pp. 3210-3215. Prepublished online as a Blood First Edition Paper on July 6, 2006; DOI 10.1182/blood-2006-04-020131. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2006-04-020131v1 108/9/3210    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Kerkhoffs, J.-L. H. Articles by Brand, A. Search for Related Content PubMed PubMed Citation Articles by Kerkhoffs, J.-L. H. Articles by Brand, A. Related Collections Transfusion Medicine Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSFUSION MEDICINE A multicenter randomized study of the efficacy of transfusions with platelets stored in platelet additive solution II versus plasma Jean-Louis H. Kerkhoffs, Jeroen C. Eikenboom, Martin S. Schipperus, Rinie J. van Wordragen-Vlaswinkel, Ronald Brand, Mark S. Harvey, Rene R. de Vries, Renee Barge, Dick J. van Rhenen, and Anneke Brand From the Sanquin Blood Bank South West Region, Rotterdam, the Netherlands; Department of Hematology, Leiden University Medical Centre, the Netherlands; Department of Medical Statistics, Leiden University Medical Centre, the Netherlands; Department of Hematology, HagaZiekenhuis, the Hague, the Netherlands; and Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, the Netherlands. Randomized studies testing the clinical efficacy of platelet additive solutions (PASs) for storage of platelets are scarce and often biased by patient selection. We conducted a multicenter, randomized study to investigate clinical efficacy of platelets stored in PAS II versus plasma, also including patients with clinical complications associated with increased platelet consumption. A total of 168 evaluable patients received pooled buffy coat–derived platelet concentrates (PCs) suspended in either plasma (n = 354) or PAS II (n = 411) stored up to 5 days. Both univariate as well as multivariate analysis showed a significant effect of used storage medium in regard to 1- and 24-hour count increments and corrected count increments, in favor of plasma PCs. However, there were no significant differences between the groups regarding bleeding complications and transfusion interval. Adverse transfusion reactions occurred significantly less after transfusions with PAS II PCs (P = .04). Multivariate analysis showed no significant effect of the used storage medium on the incidence of 1- and 24-hour transfusion failure. We showed safety and efficacy of PAS II PCs in intensively treated patients; however, plasma PCs show superior increments. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

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