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Blood, 1 January 2007, Vol. 109, No. 1, pp. 109-111. Prepublished online as a Blood First Edition Paper on August 24, 2006; DOI 10.1182/blood-2006-06-026427. This Article Full Text Full Text (PDF) Supplemental Figure All Versions of this Article: blood-2006-06-026427v1 109/1/109    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Priestley, G. V. Articles by Papayannopoulou, T. Search for Related Content PubMed PubMed Citation Articles by Priestley, G. V. Articles by Papayannopoulou, T. Related Collections Hematopoiesis and Stem Cells Stem Cells in Hematology Brief Reports Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMATOPOIESIS Brief report Sustained alterations in biodistribution of stem/progenitor cells in Tie2Cre+4f/f mice are hematopoietic cell autonomous Gregory V. Priestley1, Tatiana Ulyanova1, and Thalia Papayannopoulou1, 1 Department of Medicine/Division of Hematology, University of Washington, Seattle We have generated Tie2Cre+4f/f mice with documented 4-integrin ablation in hematopoietic and endothelial cells. A prominent feature in this model is a sustained, significant increase in circulating progenitors at levels higher than the levels seen with Tie2Cre+VCAM-1f/f mice. To test whether phenotypic differences are due to contributions by ligands other than VCAM-1 in bone marrow, or to 4-deficient endothelial cells or pericytes, we carried out transplantation experiments using these mice as donors or as recipients. Changes in progenitor biodistribution after transplantation were seen only with 4-deficient donor cells, suggesting that these cells were necessary and sufficient to reproduce the phenotype with no discernible contribution by 4-deficient nonhematopoietic cells. Because several similarities are seen after transplantation between our results and those with CXCR4–/– donor cells, the data suggest that VLA4/VCAM-1 and CXCR4/CXCL12 pathways contribute to a nonredundant, ongoing signaling required for bone marrow retention of progenitor cells during homeostasis. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Adult murine hematopoiesis can proceed without 1 and 7 integrins Gerd Bungartz, Sebastian Stiller, Martina Bauer, Werner Müller, Angela Schippers, Norbert Wagner, Reinhard Fässler, and Cord Brakebusch Blood 2006 108: 1857-1864. [Abstract] [Full Text] [PDF] This article has been cited by other articles: J. Grassinger, D. N. Haylock, M. J. Storan, G. O. Haines, B. Williams, G. A. Whitty, A. R. Vinson, C. L. Be, S. Li, E. S. Sorensen, et al. Thrombin-cleaved osteopontin regulates hemopoietic stem and progenitor cell functions through interactions with {alpha}9{beta}1 and {alpha}4{beta}1 integrins Blood, July 2, 2009; 114(1): 49 - 59. [Abstract] [Full Text] [PDF] E. G. Houston Jr., R. Nechanitzky, and P. J. Fink Cutting Edge: Contact with Secondary Lymphoid Organs Drives Postthymic T Cell Maturation J. Immunol., October 15, 2008; 181(8): 5213 - 5217. [Abstract] [Full Text] [PDF] R. Silva, G. D'Amico, K. M. Hodivala-Dilke, and L. E. Reynolds Integrins: The Keys to Unlocking Angiogenesis Arterioscler Thromb Vasc Biol, October 1, 2008; 28(10): 1703 - 1713. [Abstract] [Full Text] [PDF] L. E. Goldfinger, E. Tzima, R. Stockton, W. B. Kiosses, K. Kinbara, E. Tkachenko, E. Gutierrez, A. Groisman, P. Nguyen, S. Chien, et al. Localized {alpha}4 Integrin Phosphorylation Directs Shear Stress-Induced Endothelial Cell Alignment Circ. Res., July 18, 2008; 103(2): 177 - 185. [Abstract] [Full Text] [PDF] T. Papayannopoulou and D. T. Scadden Stem-cell ecology and stem cells in motion Blood, April 15, 2008; 111(8): 3923 - 3930. [Abstract] [Full Text] [PDF]

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