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Blood, 15 May 2007, Vol. 109, No. 10, pp. 4336-4342. Prepublished online as a Blood First Edition Paper on January 23, 2007; DOI 10.1182/blood-2006-09-046201. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2006-09-046201v1 109/10/4336    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Liu, C. Articles by Zhang, H.-G. Search for Related Content PubMed PubMed Citation Articles by Liu, C. Articles by Zhang, H.-G. Related Collections Immunobiology Immunotherapy Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Expansion of spleen myeloid suppressor cells represses NK cell cytotoxicity in tumor-bearing host Cunren Liu1, Shaohua Yu1, John Kappes2, Jianhua Wang1, William E. Grizzle3, Kurt R. Zinn4, and Huang-Ge Zhang1,5 1 Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham; 2 Department of Microbiology, University of Alabama at Birmingham; 3 Department of Pathology, University of Alabama at Birmingham; 4 Department of Radiation Oncology, University of Alabama at Birmingham; 5 Birmingham Veterans Administration Medical Center, AL Tumor growth promotes the expansion of myeloid suppressor cells. An inverse correlation between natural killer (NK) cell activation and myeloid suppressor cell (MSC) expansion in tumor-bearing patients and mice prompted us to investigate the role of MSCs in controlling NK antitumor cytotocixity. After adoptive transfer to naive recipients, CD11b+Gr-1+ MSCs freshly isolated from spleens of tumor-bearing mice but not naive mice were able to inhibit NK cell cytotoxicity. An in vivo imaging analysis indicates that the removal of tumors resulted in a significant increased ability (P < .05) in NK cell cytotoxicity to eliminate injected YAC-1 cells from the lungs. Fluorescence-activated cell sorter (FACS) analysis of the composition of lung leukocytes further indicates that the removal of tumors also leads to the reduction of MSCs accumulated in the lung. These data suggest that MSCs suppress NK cell cytotoxicity. The inhibition of NK cell cytotoxicity is cell-cell contact dependent. Inhibition of perforin but not granzyme B production was responsible for MSC-mediated inhibition of NK cytotoxicity. Western blot analyses further suggests that MSCs suppress IL-2–mediated NK cell cytotoxicity by affecting the activity of Stat5. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: D. Ilkovitch and D. M. Lopez The Liver Is a Site for Tumor-Induced Myeloid-Derived Suppressor Cell Accumulation and Immunosuppression Cancer Res., July 1, 2009; 69(13): 5514 - 5521. [Abstract] [Full Text] [PDF] S. K. Bunt, V. K. Clements, E. M. Hanson, P. Sinha, and S. Ostrand-Rosenberg Inflammation enhances myeloid-derived suppressor cell cross-talk by signaling through Toll-like receptor 4 J. Leukoc. Biol., June 1, 2009; 85(6): 996 - 1004. [Abstract] [Full Text] [PDF] D. Ilkovitch and D. M. 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