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Blood, 15 May 2007, Vol. 109, No. 10, pp. 4548-4556. Prepublished online as a Blood First Edition Paper on February 8, 2007; DOI 10.1182/blood-2006-04-017442. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2006-04-017442v1 109/10/4548    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Hossain, M. S. Articles by Waller, E. K. Search for Related Content PubMed PubMed Citation Articles by Hossain, M. S. Articles by Waller, E. K. Related Collections Immunobiology Transplantation Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSPLANTATION Chronic GvHD decreases antiviral immune responses in allogeneic BMT Mohammad S. Hossain1, John D. Roback2, Brian P. Pollack3, David L. Jaye2, Amelia Langston1, and Edmund K. Waller1 1 Department of Hematology and Oncology, Division of Stem Cell and Bone Marrow Transplantation, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA; 2 Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA; 3 Departments of Dermatology and Pathology, Emory University School of Medicine, Atlanta, GA Chronic graft-versus-host disease (cGvHD) is associated with functional immunodeficiency and an increased risk of opportunistic infections in allogeneic bone marrow transplantation (BMT). We used a parent to F1 model of allogeneic BMT to test the hypothesis that cGvHD leads to impaired antigen-specific antiviral immunity and compared BM transplant recipients with cGvHD to control groups of allogeneic BM transplant recipients without GvHD. Mice with and without cGvHD received a nonlethal dose of murine cytomegalovirus (MCMV) +100 days after transplantation. Recipients with cGvHD had more weight loss and higher viral loads in the spleen and liver. MCMV infection led to greater than 25-fold expansion of donor spleen–derived MCMV peptide–specific tetramer-positive CD8+ T cells in blood of transplant recipients with and without cGvHD, but mice with cGvHD had far fewer antigen-specific T cells in peripheral tissues and secondary lymphoid organs. The immunosuppression associated with cGvHD was confirmed by vaccinating transplant recipients with and without cGvHD using a recombinant Listeria expressing MCMV early protein (Lm-MCMV). Secondary adoptive transfer of lymphocytes from donor mice with or without cGvHD into lymphopenic congenic recipients showed that cGvHD impaired tissue-specific homing of antigen-specific T cells. These results indicate that cGvHD causes an intrinsic immunosuppression and explain, in part, the functional immunodeficiency in allogeneic transplant recipients. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. Janin, H. Murata, C. Leboeuf, J.-M. Cayuela, E. Gluckman, L. Legres, A. Desveaux, M. Varna, P. Ratajczak, J. Soulier, et al. Donor-derived oral squamous cell carcinoma after allogeneic bone marrow transplantation Blood, February 19, 2009; 113(8): 1834 - 1840. [Abstract] [Full Text] [PDF] M. S. Hossain, J. D. Roback, F. Wang, and E. K. Waller Host and Donor Immune Responses Contribute to Antiviral Effects of Amotosalen-Treated Donor Lymphocytes following Early Posttransplant Cytomegalovirus Infection J. Immunol., May 15, 2008; 180(10): 6892 - 6902. [Abstract] [Full Text] [PDF]

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