SEARCH:   Advanced

Blood, 15 May 2007, Vol. 109, No. 10, pp. 4575-4581. Prepublished online as a Blood First Edition Paper on February 1, 2007; DOI 10.1182/blood-2006-07-029090. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2006-07-029090v1 109/10/4575    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Cavazzana-Calvo, M. Articles by Hacein-Bey-Abina, S. Search for Related Content PubMed PubMed Citation Articles by Cavazzana-Calvo, M. Articles by Hacein-Bey-Abina, S. Related Collections Immunobiology Transplantation Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSPLANTATION Long-term T-cell reconstitution after hematopoietic stem-cell transplantation in primary T-cell–immunodeficient patients is associated with myeloid chimerism and possibly the primary disease phenotype Marina Cavazzana-Calvo1,2, Frédérique Carlier2, Françoise Le Deist3, Estelle Morillon1, Pierre Taupin4, David Gautier5, Isabelle Radford-Weiss6, Sophie Caillat-Zucman7, Bénédicte Neven8, Stephane Blanche8, Rémi Cheynier5, Alain Fischer1,8, and Salima Hacein-Bey-Abina1,2 1 Institut National de la Santé et de la Recherche Médicale (INSERM), Unité (U) 768, Paris, France; Université René Descartes, Paris, France; Hôpital Necker–Enfants Malades, Paris, France; 2 Département de Biothérapies, Assistance Publique des Hôpitaux de Paris (AP-HP), Hôpital Necker–Enfants Malades, Paris, France; 3 Centre d'Etude des Déficits Immunitaires, Hôpital Necker–Enfants Malades, Paris, France; 4 Département de Biostatistique–Hôpital Necker–Enfants Malades, Paris, France; 5 Unité des Virus Lents, Institut Pasteur, Paris; 6 Laboratoire de cytogénétique, Hôpital Necker–Enfants Malades, Paris, France; 7 Laboratoire d'Immunologie, Hôpital Necker–Enfants Malades, Paris, France; 8 Unité d'Immunologie et Hématologie Pédiatrique, Hôpital Necker–Enfants Malades, Paris, France We studied T-cell reconstitution in 31 primary T-cell–immunodeficient patients who had undergone hematopoietic stem-cell transplantation (HSCT) over 10 years previously. In 19 patients, there was no evidence of myeloid chimerism because little or no myeloablation had been performed. Given this context, we sought factors associated with good long-term T-cell reconstitution. We found that all patients having undergone full myeloablation had donor myeloid cells and persistent thymopoiesis, as evidenced by the presence of naive T cells carrying T-cell receptor excision circles (TRECs). In 9 patients with host myeloid chimerism, sustained thymic output was also observed and appeared to be associated with c deficiency. It is therefore possible that the complete absence of thymic progenitors characterizing this condition created a more favorable environment for thymic seeding by a population of early progenitor cells with the potential for self-renewal, thus enabling long-term (> 10 years) T-cell production. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: D. Bhattacharya, A. Czechowicz, A.G. L. Ooi, D. J. Rossi, D. Bryder, and I. L. Weissman Niche recycling through division-independent egress of hematopoietic stem cells J. Exp. Med., November 2, 2009; (2009) jem.20090778v1. [Abstract] [Full Text] [PDF] F. T. Hakim TRECing long-term success in SCID Blood, August 13, 2009; 114(7): 1287 - 1288. [Full Text] [PDF] M. Sarzotti-Kelsoe, C. M. Win, R. E. Parrott, M. Cooney, B. K. Moser, J. L. Roberts, G. D. Sempowski, and R. H. Buckley Thymic output, T-cell diversity, and T-cell function in long-term human SCID chimeras Blood, August 13, 2009; 114(7): 1445 - 1453. [Abstract] [Full Text] [PDF] B. Neven, S. Leroy, H. Decaluwe, F. Le Deist, C. Picard, D. Moshous, N. Mahlaoui, M. Debre, J.-L. Casanova, L. Dal Cortivo, et al. Long-term outcome after hematopoietic stem cell transplantation of a single-center cohort of 90 patients with severe combined immunodeficiency Blood, April 23, 2009; 113(17): 4114 - 4124. [Abstract] [Full Text] [PDF] S. Amorosi, I. Russo, G. Amodio, C. Garbi, L. Vitiello, L. Palamaro, M. Adriani, I. Vigliano, and C. Pignata The Cellular Amount of the Common {gamma}-Chain Influences Spontaneous or Induced Cell Proliferation J. Immunol., March 1, 2009; 182(5): 3304 - 3309. [Abstract] [Full Text] [PDF] S. I. Alexander, N. Smith, M. Hu, D. Verran, A. Shun, S. Dorney, A. Smith, B. Webster, P. J. Shaw, A. Lammi, et al. Chimerism and Tolerance in a Recipient of a Deceased-Donor Liver Transplant N. Engl. J. Med., January 24, 2008; 358(4): 369 - 374. [Abstract] [Full Text] [PDF] A. Czechowicz, D. Kraft, I. L. Weissman, and D. Bhattacharya Efficient Transplantation via Antibody-Based Clearance of Hematopoietic Stem Cell Niches Science, November 23, 2007; 318(5854): 1296 - 1299. [Abstract] [Full Text] [PDF]

	Copyright © 2007 by American Society of Hematology         Online ISSN: 1528-0020