SEARCH:   Advanced

Blood, 1 June 2007, Vol. 109, No. 11, pp. 4663-4670. Prepublished online as a Blood First Edition Paper on February 6, 2007; DOI 10.1182/blood-2006-10-055384. This Article Full Text Full Text (PDF) Supplemental Appendix All Versions of this Article: blood-2006-10-055384v1 109/11/4663    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Patel, K. V. Articles by Guralnik, J. M. Search for Related Content PubMed PubMed Citation Articles by Patel, K. V. Articles by Guralnik, J. M. Related Collections Red Cells Clinical Trials and Observations Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CLINICAL TRIALS AND OBSERVATIONS Racial variation in the relationship of anemia with mortality and mobility disability among older adults Kushang V. Patel1, Tamara B. Harris1, Marion Faulhaber1, Sara B. Angleman1, Stephanie Connelly2, Douglas C. Bauer3, Lewis H. Kuller4, Anne B. Newman4, Jack M. Guralnik, for the Health, Aging, and Body Composition Study1 1 Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD; 2 Department of Preventive Medicine, University of Tennessee, Memphis; 3 Departments of Medicine and Epidemiology and Biostatistics, University of California, San Francisco; 4 Departments of Epidemiology and Medicine, University of Pittsburgh, PA Anemia is more common among older blacks than older whites. However, it is unclear whether anemia predicts adverse events similarly in both races. Data on 1018 black and 1583 white adults aged 71 to 82 years were analyzed. Anemia, as defined by World Health Organization (WHO) criteria, was used to predict mortality over 6 years and incidence of mobility disability over 4 years. In proportional hazards models of mortality in whites, the age-adjusted hazard ratio (HR) for anemia in men was 1.96 (95% confidence interval [CI]: 1.35, 2.83) and in women was 2.86 (95% CI: 1.69, 4.82). In contrast, anemia was not associated with mortality in black men (HR = 1.15 [95% CI: 0.77, 1.72]) or women (HR = 1.39 [95% CI: 0.91, 2.14]). Higher mortality rate was observed only in black men with hemoglobin values more than 20 g/L (2.0 g/dL) below the WHO cutoff, whereas mortality rates were elevated in white men with hemoglobin values 1 to 10, 11 to 20, and more than 20 g/L below the WHO cutoff. In conclusion, anemia was significantly associated with increased risk of death and mobility disability in community-dwelling older whites. Conversely, older blacks classified as anemic by WHO criteria were not at risk for adverse events, indicating that alternative criteria are warranted. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Further epidemiologic research on anemia in older adults is needed Kushang V. Patel, Tamara B. Harris, Anne B. Newman, and Jack M. Guralnik Blood 2008 111: 2941-2942. [Full Text] [PDF] This article has been cited by other articles: N. A. Zakai, L. A. McClure, R. Prineas, G. Howard, W. McClellan, C. E. Holmes, B. B. Newsome, D. G. Warnock, P. Audhya, and M. Cushman Correlates of Anemia in American Blacks and Whites: The REGARDS Renal Ancillary Study Am. J. Epidemiol., February 1, 2009; 169(3): 355 - 364. [Abstract] [Full Text] [PDF] K. V. Patel and J. M. Guralnik Prognostic implications of anemia in older adults Haematologica, January 1, 2009; 94(1): 1 - 2. [Full Text] [PDF] E. Riva, M. Tettamanti, P. Mosconi, G. Apolone, F. Gandini, A. Nobili, M. V. Tallone, P. Detoma, A. Giacomin, M. Clerico, et al. Association of mild anemia with hospitalization and mortality in the elderly: the Health and Anemia population-based study Haematologica, January 1, 2009; 94(1): 22 - 28. [Abstract] [Full Text] [PDF] K. V. Patel Variability and heritability of hemoglobin concentration: an opportunity to improve understanding of anemia in older adults Haematologica, September 1, 2008; 93(9): 1281 - 1283. [Full Text] [PDF] C. Sala, M. Ciullo, C. Lanzara, T. Nutile, S. Bione, R. Massacane, P. d'Adamo, P. Gasparini, D. Toniolo, and C. Camaschella Variation of hemoglobin levels in normal Italian populations from genetic isolates Haematologica, September 1, 2008; 93(9): 1372 - 1375. [Abstract] [Full Text] [PDF] X. Dong, C. M. de Leon, A. Artz, Y. Tang, R. Shah, and D. Evans A Population-Based Study of Hemoglobin, Race, and Mortality in Elderly Persons J. Gerontol. A Biol. Sci. Med. Sci., August 1, 2008; 63(8): 873 - 878. [Abstract] [Full Text] [PDF] A. Artz and X. Dong Defining anemia by race using epidemiologic data Blood, March 1, 2008; 111(5): 2941 - 2941. [Full Text] [PDF] K. V. Patel, T. B. Harris, A. B. Newman, and J. M. Guralnik Further epidemiologic research on anemia in older adults is needed Blood, March 1, 2008; 111(5): 2941 - 2942. [Full Text] [PDF] M. Cazzola, M. G. Della Porta, and L. Malcovati Clinical Relevance of Anemia and Transfusion Iron Overload in Myelodysplastic Syndromes Hematology, January 1, 2008; 2008(1): 166 - 175. [Abstract] [Full Text] [PDF] D. P. Steensma and A. Tefferi Anemia in the Elderly: How Should We Define It, When Does It Matter, and What Can Be Done? Mayo Clin. Proc., August 1, 2007; 82(8): 958 - 966. [Abstract] [Full Text] [PDF]

	Copyright © 2007 by American Society of Hematology         Online ISSN: 1528-0020