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 Blood, 1 June 2007, Vol. 109, No. 11, pp. 4786-4792.
Prepublished online as a Blood First Edition Paper on February 15, 2007; DOI 10.1182/blood-2006-07-038539.

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HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Moderation of the platelet releasate response by aspirin

Judith A. Coppinger1, Roisin O'Connor2, Kieran Wynne2, Michelle Flanagan2, Matthew Sullivan2, Patricia B. Maguire3, Desmond J. Fitzgerald3, and Gerard Cagney2,4

1 Scripps Research Institute, Department of Cell Biology, La Jolla, CA; 2 School of Biomolecular & Biomedical Science, Conway Institute, University College Dublin, Ireland; 3 School of Medicine and Medical Science, University College Dublin, Ireland; 4 Proteome Research Center, Conway Institute, University College Dublin, Ireland

Modulation of the proteins released during activation is one mechanism whereby aspirin may influence platelet-mediated human disease. We investigated the effect of aspirin on the platelet releasate using mass spectrometry and found that different agonists evoked different releasate profiles, with aspirin having a general moderating effect on the amount of protein released regardless of the agonist. These observations were confirmed for several cytokines using an antibody array approach.


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