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Blood, 1 June 2007, Vol. 109, No. 11, pp. 4930-4935. Prepublished online as a Blood First Edition Paper on February 13, 2007; DOI 10.1182/blood-2006-09-047068. This Article Full Text Full Text (PDF) Supplemental Tables All Versions of this Article: blood-2006-09-047068v1 109/11/4930    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Nyman, H. Articles by Leppä, S. Search for Related Content PubMed PubMed Citation Articles by Nyman, H. Articles by Leppä, S. Related Collections Immunobiology Neoplasia Immunotherapy Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  NEOPLASIA Prognostic impact of immunohistochemically defined germinal center phenotype in diffuse large B-cell lymphoma patients treated with immunochemotherapy Heidi Nyman1,2, Magdalena Adde3, Marja-Liisa Karjalainen-Lindsberg4, Minna Taskinen1,2, Mattias Berglund3, Rose-Marie Amini5, Carl Blomqvist1,3, Gunilla Enblad3, and Sirpa Leppä1,2 1 Department of Oncology, Helsinki University Central Hospital, Finland; 2 Molecular Cancer Biology Research Program, Biomedicum Helsinki, University of Helsinki, Finland; 3 Department of Oncology, Uppsala University Hospital, Sweden; 4 Department of Pathology, Haartman Institute, University of Helsinki, Finland; 5 Department of Genetics and Pathology, University of Uppsala, Sweden Germinal center (GC) and non-GC phenotypes are predictors of outcome in diffuse large B-cell lymphoma (DLBCL) and can be used to stratify chemotherapy-treated patients into low- and high-risk groups. To determine how combination of rituximab with chemotherapy influences GC-associated clinical outcome, GC and non-GC phenotypes were identified immunohistochemically from samples of 90 de novo DLBCL patients treated with rituximab in combination with CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone)–like regimen (immunochemotherapy). One hundred and four patients previously treated with chemotherapy served as a control group. Consistent with previous studies, chemotherapy-treated patients with immunohistochemically defined GC phenotype displayed a significantly better overall (OS) and failure-free survival (FFS) than the non-GC group (OS, 70% vs 47%, P = .012; FFS, 59% vs 30%, P = .001). In contrast, immunohistochemically defined GC phenotype did not predict outcome in immunochemotherapy-treated patients (OS, 77% vs 76%, P = ns; FFS, 68% vs 63%, P = ns). In comparison, International Prognostic Index (IPI) could separate the high-risk patients from low- and intermediate-risk groups (OS, 84% vs 63%, P = .030; FFS, 79% vs 52%, P = .028). We conclude that rituximab in combination with chemotherapy seems to eliminate the prognostic value of immunohistochemically defined GC- and non-GC phenotypes in DLBCL. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C. Copie-Bergman, P. Gaulard, K. Leroy, J. Briere, M. Baia, J.-P. Jais, G. A. Salles, F. Berger, C. Haioun, H. Tilly, et al. Immuno-Fluorescence In Situ Hybridization Index Predicts Survival in Patients With Diffuse Large B-Cell Lymphoma Treated With R-CHOP: A GELA Study J. Clin. Oncol., November 20, 2009; 27(33): 5573 - 5579. [Abstract] [Full Text] [PDF] R. Seki, K. Ohshima, T. Fujisaki, N. Uike, F. Kawano, H. Gondo, S. Makino, T. Eto, Y. Moriuchi, F. Taguchi, et al. Prognostic significance of S-phase kinase-associated protein 2 and p27kip1 in patients with diffuse large B-cell lymphoma: effects of rituximab Ann. Onc., November 4, 2009; (2009) mdp481v1. [Abstract] [Full Text] [PDF] M.-K. Song, J.-S. Chung, Y.-M. Seol, S.-G. Kim, H.-J. Shin, Y.-J. Choi, G.-J. Cho, and D.-H. Shin Influence of low absolute lymphocyte count of patients with nongerminal center type diffuse large B-cell lymphoma with R-CHOP therapy Ann. Onc., November 3, 2009; (2009) mdp505v1. [Abstract] [Full Text] [PDF] D. Ennishi, H. Asai, Y. Maeda, K. Shinagawa, K. Ikeda, M. Yokoyama, Y. Terui, K. Takeuchi, T. Yoshino, K. Matsuo, et al. Statin-independent prognosis of patients with diffuse large B-cell lymphoma receiving rituximab plus CHOP therapy Ann. Onc., November 2, 2009; (2009) mdp490v1. [Abstract] [Full Text] [PDF] H.-W. Bernd, M. Ziepert, C. Thorns, W. Klapper, H.-H. Wacker, M. Hummel, H. Stein, M.-L. Hansmann, G. Ott, A. Rosenwald, et al. Loss of HLA-DR expression and immunoblastic morphology predict adverse outcome in diffuse large B-cell lymphoma - analyses of cases from two prospective randomized clinical trials Haematologica, November 1, 2009; 94(11): 1569 - 1580. [Abstract] [Full Text] [PDF] A. Chadburn, A. Chiu, J. Y. Lee, X. Chen, E. Hyjek, A. H. Banham, A. Noy, L. D. Kaplan, J. A. Sparano, K. Bhatia, et al. Immunophenotypic Analysis of AIDS-Related Diffuse Large B-Cell Lymphoma and Clinical Implications in Patients From AIDS Malignancies Consortium Clinical Trials 010 and 034 J. Clin. Oncol., October 20, 2009; 27(30): 5039 - 5048. [Abstract] [Full Text] [PDF] W. W.L. Choi, D. D. Weisenburger, T. C. Greiner, M. A. Piris, A. H. Banham, J. Delabie, R. M. Braziel, H. Geng, J. Iqbal, G. Lenz, et al. A New Immunostain Algorithm Classifies Diffuse Large B-Cell Lymphoma into Molecular Subtypes with High Accuracy Clin. Cancer Res., September 1, 2009; 15(17): 5494 - 5502. [Abstract] [Full Text] [PDF] D. Ennishi, M. 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