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Blood, 15 June 2007, Vol. 109, No. 12, pp. 5230-5233. Prepublished online as a Blood First Edition Paper on March 5, 2007; DOI 10.1182/blood-2007-02-072983. This Article Full Text Full Text (PDF) Supplemental Methods and Figures All Versions of this Article: blood-2007-02-072983v1 109/12/5230    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Johnson, K. D. Articles by Bresnick, E. H. Search for Related Content PubMed PubMed Citation Articles by Johnson, K. D. Articles by Bresnick, E. H. Related Collections Hemostasis, Thrombosis, and Vascular Biology Red Cells Gene Expression Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMATOPOIESIS Brief Report Friend of GATA-1–independent transcriptional repression: a novel mode of GATA-1 function Kirby D. Johnson1, Meghan E. Boyer1, Jeong-Ah Kang2, Amittha Wickrema2, Alan B. Cantor3, and Emery H. Bresnick1 1 Department of Pharmacology, University of Wisconsin School of Medicine, Madison; 2 Section of Hematology Oncology, University of Chicago, IL; 3 Division of Pediatric Hematology/Oncology, Children's Hospital Boston, MA The GATA-1–interacting protein Friend Of GATA-1 (FOG-1) is essential for the proper transcriptional activation and repression of numerous GATA-1 target genes. Although FOG-1–independent activation by GATA-1 has been described, all known examples of GATA-1–mediated repression are FOG-1 dependent. In the GATA-1–null G1E cell line, estrogen receptor ligand binding domain (ER) chimeras of either wild-type GATA-1 or a FOG-1–binding defective mutant of GATA-1 repressed several genes similarly upon activation with ß-estradiol. Repression also occurred in a FOG-1–null cell line expressing ER–GATA-1 and during ex vivo erythropoiesis. At the Lyl1 and Rgs18 loci, we found highly restricted occupancy by GATA-1 and GATA-2, indicating that these genes are direct targets of GATA factor regulation. The identification of genes repressed by GATA-1 independent of FOG-1 defines a novel mode of GATA-1–mediated transcriptional regulation. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: L. A. Steiner, Y. Maksimova, V. Schulz, C. Wong, D. Raha, M. C. Mahajan, S. M. Weissman, and P. G. Gallagher Chromatin Architecture and Transcription Factor Binding Regulate Expression of Erythrocyte Membrane Protein Genes Mol. Cell. Biol., October 15, 2009; 29(20): 5399 - 5412. [Abstract] [Full Text] [PDF] S. T. Chou, E. Khandros, L. C. Bailey, K. E. Nichols, C. R. Vakoc, Y. Yao, Z. Huang, J. D. Crispino, R. C. Hardison, G. A. Blobel, et al. Graded repression of PU.1/Sfpi1 gene transcription by GATA factors regulates hematopoietic cell fate Blood, July 30, 2009; 114(5): 983 - 994. [Abstract] [Full Text] [PDF] T. Tripic, W. Deng, Y. Cheng, Y. Zhang, C. R. Vakoc, G. D. Gregory, R. C. Hardison, and G. A. Blobel SCL and associated proteins distinguish active from repressive GATA transcription factor complexes Blood, March 5, 2009; 113(10): 2191 - 2201. [Abstract] [Full Text] [PDF] G. Hua, B. Zhu, F. Rosa, N. Deblon, J. Adelaide, B. Kahn-Perles, D. Birnbaum, and J. Imbert A Negative Feedback Regulatory Loop Associates the Tyrosine Kinase Receptor ERBB2 and the Transcription Factor GATA4 in Breast Cancer Cells Mol. Cancer Res., March 1, 2009; 7(3): 402 - 414. [Abstract] [Full Text] [PDF] R. J. Wozniak, S. Keles, J. J. Lugus, K. H. Young, M. E. Boyer, T. M. Tran, K. Choi, and E. H. Bresnick Molecular Hallmarks of Endogenous Chromatin Complexes Containing Master Regulators of Hematopoiesis Mol. Cell. Biol., November 1, 2008; 28(21): 6681 - 6694. [Abstract] [Full Text] [PDF] T. Sengupta, K. Chen, E. Milot, and J. J. Bieker Acetylation of EKLF Is Essential for Epigenetic Modification and Transcriptional Activation of the {beta}-Globin Locus Mol. Cell. Biol., October 15, 2008; 28(20): 6160 - 6170. [Abstract] [Full Text] [PDF] C. R. Scherzer, J. A. Grass, Z. Liao, I. Pepivani, B. Zheng, A. C. Eklund, P. A. Ney, J. Ng, M. McGoldrick, B. Mollenhauer, et al. GATA transcription factors directly regulate the Parkinson's disease-linked gene {alpha}-synuclein PNAS, August 5, 2008; 105(31): 10907 - 10912. [Abstract] [Full Text] [PDF] S.-I. Kim, S. J. Bultman, H. Jing, G. A. Blobel, and E. H. Bresnick Dissecting Molecular Steps in Chromatin Domain Activation during Hematopoietic Differentiation Mol. Cell. Biol., June 15, 2007; 27(12): 4551 - 4565. [Abstract] [Full Text] [PDF]

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