Blood online
Home About Blood Authors Subscriptions Permission Advertising Public Access contact us
 

 
Advanced
Current Issue
First Edition
Future Articles
Archives
Submit to Blood
Search
American Society of Hematology
Meeting Abstracts
Email Alerts
Blood, 15 June 2007, Vol. 109, No. 12, pp. 5230-5233.
Prepublished online as a Blood First Edition Paper on March 5, 2007; DOI 10.1182/blood-2007-02-072983.


This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental Methods and Figures
Right arrow All Versions of this Article:
blood-2007-02-072983v1
109/12/5230    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Right arrow Rights and Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Johnson, K. D.
Right arrow Articles by Bresnick, E. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Johnson, K. D.
Right arrow Articles by Bresnick, E. H.
Related Collections
Right arrow Hemostasis, Thrombosis, and Vascular Biology
Right arrow Red Cells
Right arrow Gene Expression
Right arrow Brief Reports
Social Bookmarking
 Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

arrow to previous article Previous Article  |  Table of Contents  |  Next Article next article arrow

HEMATOPOIESIS

Brief Report

Friend of GATA-1–independent transcriptional repression: a novel mode of GATA-1 function

Kirby D. Johnson1, Meghan E. Boyer1, Jeong-Ah Kang2, Amittha Wickrema2, Alan B. Cantor3, and Emery H. Bresnick1

1 Department of Pharmacology, University of Wisconsin School of Medicine, Madison; 2 Section of Hematology Oncology, University of Chicago, IL; 3 Division of Pediatric Hematology/Oncology, Children's Hospital Boston, MA

The GATA-1–interacting protein Friend Of GATA-1 (FOG-1) is essential for the proper transcriptional activation and repression of numerous GATA-1 target genes. Although FOG-1–independent activation by GATA-1 has been described, all known examples of GATA-1–mediated repression are FOG-1 dependent. In the GATA-1–null G1E cell line, estrogen receptor ligand binding domain (ER) chimeras of either wild-type GATA-1 or a FOG-1–binding defective mutant of GATA-1 repressed several genes similarly upon activation with ß-estradiol. Repression also occurred in a FOG-1–null cell line expressing ER–GATA-1 and during ex vivo erythropoiesis. At the Lyl1 and Rgs18 loci, we found highly restricted occupancy by GATA-1 and GATA-2, indicating that these genes are direct targets of GATA factor regulation. The identification of genes repressed by GATA-1 independent of FOG-1 defines a novel mode of GATA-1–mediated transcriptional regulation.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
Mol. Cell. Biol.Home page
L. A. Steiner, Y. Maksimova, V. Schulz, C. Wong, D. Raha, M. C. Mahajan, S. M. Weissman, and P. G. Gallagher
Chromatin Architecture and Transcription Factor Binding Regulate Expression of Erythrocyte Membrane Protein Genes
Mol. Cell. Biol., October 15, 2009; 29(20): 5399 - 5412.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
S. T. Chou, E. Khandros, L. C. Bailey, K. E. Nichols, C. R. Vakoc, Y. Yao, Z. Huang, J. D. Crispino, R. C. Hardison, G. A. Blobel, et al.
Graded repression of PU.1/Sfpi1 gene transcription by GATA factors regulates hematopoietic cell fate
Blood, July 30, 2009; 114(5): 983 - 994.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
T. Tripic, W. Deng, Y. Cheng, Y. Zhang, C. R. Vakoc, G. D. Gregory, R. C. Hardison, and G. A. Blobel
SCL and associated proteins distinguish active from repressive GATA transcription factor complexes
Blood, March 5, 2009; 113(10): 2191 - 2201.
[Abstract] [Full Text] [PDF]


Home page
Mol Cancer ResHome page
G. Hua, B. Zhu, F. Rosa, N. Deblon, J. Adelaide, B. Kahn-Perles, D. Birnbaum, and J. Imbert
A Negative Feedback Regulatory Loop Associates the Tyrosine Kinase Receptor ERBB2 and the Transcription Factor GATA4 in Breast Cancer Cells
Mol. Cancer Res., March 1, 2009; 7(3): 402 - 414.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
R. J. Wozniak, S. Keles, J. J. Lugus, K. H. Young, M. E. Boyer, T. M. Tran, K. Choi, and E. H. Bresnick
Molecular Hallmarks of Endogenous Chromatin Complexes Containing Master Regulators of Hematopoiesis
Mol. Cell. Biol., November 1, 2008; 28(21): 6681 - 6694.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
T. Sengupta, K. Chen, E. Milot, and J. J. Bieker
Acetylation of EKLF Is Essential for Epigenetic Modification and Transcriptional Activation of the {beta}-Globin Locus
Mol. Cell. Biol., October 15, 2008; 28(20): 6160 - 6170.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
C. R. Scherzer, J. A. Grass, Z. Liao, I. Pepivani, B. Zheng, A. C. Eklund, P. A. Ney, J. Ng, M. McGoldrick, B. Mollenhauer, et al.
GATA transcription factors directly regulate the Parkinson's disease-linked gene {alpha}-synuclein
PNAS, August 5, 2008; 105(31): 10907 - 10912.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
S.-I. Kim, S. J. Bultman, H. Jing, G. A. Blobel, and E. H. Bresnick
Dissecting Molecular Steps in Chromatin Domain Activation during Hematopoietic Differentiation
Mol. Cell. Biol., June 15, 2007; 27(12): 4551 - 4565.
[Abstract] [Full Text] [PDF]



 click for free articles
home about blood authors subscriptions permissions advertising public access contact us
  Copyright © 2007 by American Society of Hematology         Online ISSN: 1528-0020