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Blood, 15 June 2007, Vol. 109, No. 12, pp. 5346-5354. Prepublished online as a Blood First Edition Paper on February 27, 2007; DOI 10.1182/blood-2006-10-051318. This Article Full Text Full Text (PDF) Supplemental Figures All Versions of this Article: blood-2006-10-051318v1 109/12/5346    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Perez-Diez, A. Articles by Matzinger, P. Search for Related Content PubMed PubMed Citation Articles by Perez-Diez, A. Articles by Matzinger, P. Related Collections Immunobiology Immunotherapy Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY CD4 cells can be more efficient at tumor rejection than CD8 cells Ainhoa Perez-Diez1, Nathalie T. Joncker3, Kyungho Choi2, William F. N. Chan4, Colin C. Anderson4,5, Olivier Lantz3, and Polly Matzinger1 From the 1 Ghost Lab 2 Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD; 3 Laboratoire d'Immunologie and U520 Institut National de la Santé et de la Recherche Médicale, Institute Curie, Paris, France; and Departments of 4 Medical Microbiology & Immunology and 5 Surgery, University of Alberta, Edmonton, AB, Canada Researchers designing antitumor treatments have long focused on eliciting tumor-specific CD8 cytotoxic T lymphocytes (CTL) because of their potent killing activity and their ability to reject transplanted organs. The resulting treatments, however, have generally been surprisingly poor at inducing complete tumor rejection, both in experimental models and in the clinic. Although a few scattered studies suggested that CD4 T "helper" cells might also serve as antitumor effectors, they have generally been studied mostly for their ability to enhance the activity of CTL. In this mouse study, we compared monoclonal populations of tumor-specific CD4 and CD8 T cells as effectors against several different tumors, and found that CD4 T cells eliminated tumors that were resistant to CD8-mediated rejection, even in cases where the tumors expressed major histocompatibility complex (MHC) class I molecules but not MHC class II. MHC class II expression on host tissues was critical, suggesting that the CD4 T cells act indirectly. Indeed, the CD4 T cells partnered with NK cells to obtain the maximal antitumor effect. These findings suggest that CD4 T cells can be powerful antitumor effector cells that can, in some cases, outperform CD8 T cells, which are the current "gold standard" effector cell in tumor immunotherapy. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Antitumor T-cell wars: do CD4s outwit CD8s? Ignacio Melero Blood 2007 109: 5070-5071. [Full Text] [PDF] This article has been cited by other articles: W. Jing, J. A. Gershan, and B. D. Johnson Depletion of CD4 T cells enhances immunotherapy for neuroblastoma after syngeneic HSCT but compromises development of antitumor immune memory Blood, April 30, 2009; 113(18): 4449 - 4457. [Abstract] [Full Text] [PDF] A. Ziegler, R. Heidenreich, H. Braumuller, H. Wolburg, S. Weidemann, R. Mocikat, and M. Rocken EpCAM, a human tumor-associated antigen promotes Th2 development and tumor immune evasion Blood, April 9, 2009; 113(15): 3494 - 3502. [Abstract] [Full Text] [PDF] M. Y. Gerner and M. F. Mescher Antigen Processing and MHC-II Presentation by Dermal and Tumor-Infiltrating Dendritic Cells J. Immunol., March 1, 2009; 182(5): 2726 - 2737. [Abstract] [Full Text] [PDF] C. 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