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 Blood, 15 June 2007, Vol. 109, No. 12, pp. 5407-5410.
Prepublished online as a Blood First Edition Paper on March 9, 2007; DOI 10.1182/blood-2006-08-039446.

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Brief Report

A novel proteoliposomal vaccine elicits potent antitumor immunity in mice

Mircea C. Popescu1, Richard J. Robb1, Michael M. Batenjany2, Lawrence T. Boni2, Mary E. Neville2, Robin W. Pennington3, Sattva S. Neelapu4, and Larry W. Kwak4

1 XEME Biopharma, Plainsboro, NJ; 2 Biomira USA, Cranbury, NJ; 3 Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institute of Health, Bethesda, MD; 4 Department of Lymphoma and Myeloma, University of Texas M. D. Anderson Cancer Center, Houston

Therapeutic vaccination against idiotype is a promising strategy for immunotherapy of B-cell malignancies. Its feasibility, however, is limited by the requirement for a patient-specific product. Here we describe a novel vaccine formulation prepared by simply extracting cell-membrane proteins from lymphoma cells and incorporating them together with IL-2 into proteoliposomes. The vaccine was produced in 24 hours, compared with more labor-intensive and time-consuming hybridoma or recombinant DNA methods. The vaccine elicited T-cell immunity in vivo, as demonstrated by secretion of type 1 cytokines. It protected against tumor challenge at doses of tumor antigen 50 to 100 times lower than that previously observed using either liposomes formulated with IL-2 and secreted lymphoma immunoglobulin or a prototype vaccine consisting of lymphoma immunoglobulin conjugated to keyhole limpet hemocyanin. The increased potency justifies testing similar patient-specific human vaccines prepared using extracts from primary tumor samples.


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S. S. Neelapu and L. W. Kwak
Vaccine Therapy for B-Cell Lymphomas: Next-Generation Strategies
Hematology, January 1, 2007; 2007(1): 243 - 249.
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