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Blood, 15 January 2007, Vol. 109, No. 2, pp. 661-669. Prepublished online as a Blood First Edition Paper on September 26, 2006; DOI 10.1182/blood-2005-12-023044. This Article Full Text Full Text (PDF) Supplemental Figures All Versions of this Article: blood-2005-12-023044v1 109/2/661    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Varga, G. Articles by Grabbe, S. Search for Related Content PubMed PubMed Citation Articles by Varga, G. Articles by Grabbe, S. Related Collections Immunobiology Cell Adhesion and Motility Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Active MAC-1 (CD11b/CD18) on DCs inhibits full T-cell activation Georg Varga1, Sandra Balkow1, Martin K. Wild2,3, Andrea Stadtbaeumer1, Mathias Krummen1, Tobias Rothoeft1, Tetsuya Higuchi1, Stefan Beissert1, Klaus Wethmar3,4, Karin Scharffetter-Kochanek5, Dietmar Vestweber2,3, and Stephan Grabbe1,6, 1 Cell Biology, Department of Dermatology, University of Münster, Germany; 2 Center for Molecular Biology of Inflammation, University of Münster, Germany; 3 Max-Planck-Institute for Molecular Biomedicine, Münster, Germany; 4 Max-Delbrück-Center for Molecular Medicine, Berlin-Buch, Germany; 5 Department of Dermatology, University of Ulm, Germany; 6 Department of Dermatology, University of Essen, Germany The ß2 integrins are important for transendothelial migration of leukocytes as well as for T-cell activation during antigen presentation. Despite abundant expression of ß2 integrins on antigen-presenting cells (APCs), their functional relevance for antigen presentation is completely unclear. We show here that dendritic cells (DCs) from CD18-deficient mice, which lack all functional ß2 integrins, have no defect in antigen presentation. Moreover, DCs from normal mice express inactive ß2 integrins that do not become activated on contact with T cells, at least in vitro. Pharmacologic activation of ß2 integrins on DCs results in a significant reduction of their T cell–activating capacity. This effect is mediated by Mac-1 (CD11b/CD18) on DCs because it could be reversed via blocking antibodies against CD18 and CD11b. Furthermore, the antigen-presenting capacity of macrophages, which express constitutively active ß2 integrins, is significantly enhanced on Mac-1 blockade. We therefore conclude that active CD11b/CD18 (Mac-1) on APCs directly inhibits T-cell activation. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. Sekine, K. Kataoka, Y. Fukuyama, Y. Adachi, J. Davydova, M. Yamamoto, R. Kobayashi, K. Fujihashi, H. Suzuki, D. T. Curiel, et al. A Novel Adenovirus Expressing Flt3 Ligand Enhances Mucosal Immunity by Inducing Mature Nasopharyngeal-Associated Lymphoreticular Tissue Dendritic Cell Migration J. Immunol., June 15, 2008; 180(12): 8126 - 8134. [Abstract] [Full Text] [PDF] I. Valera, N. Fernandez, A. G. Trinidad, S. Alonso, G. D. Brown, A. Alonso, and M. S. Crespo Costimulation of Dectin-1 and DC-SIGN Triggers the Arachidonic Acid Cascade in Human Monocyte-Derived Dendritic Cells J. Immunol., April 15, 2008; 180(8): 5727 - 5736. [Abstract] [Full Text] [PDF] K. Shimizu, P. Libby, R. Shubiki, M. Sakuma, Y. Wang, K. Asano, R. N. Mitchell, and D. I. Simon Leukocyte Integrin Mac-1 Promotes Acute Cardiac Allograft Rejection Circulation, April 15, 2008; 117(15): 1997 - 2008. [Abstract] [Full Text] [PDF] S. Balkow, F. Krux, K. Loser, J. U. Becker, S. Grabbe, and U. Dittmer Friend retrovirus infection of myeloid dendritic cells impairs maturation, prolongs contact to naive T cells, and favors expansion of regulatory T cells Blood, December 1, 2007; 110(12): 3949 - 3958. [Abstract] [Full Text] [PDF] E. Segura, C. Guerin, N. Hogg, S. Amigorena, and C. Thery CD8+ Dendritic Cells Use LFA-1 to Capture MHC-Peptide Complexes from Exosomes In Vivo J. Immunol., August 1, 2007; 179(3): 1489 - 1496. [Abstract] [Full Text] [PDF]

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