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Blood, 15 January 2007, Vol. 109, No. 2, pp. 683-692. Prepublished online as a Blood First Edition Paper on September 28, 2006; DOI 10.1182/blood-2006-02-003236. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2006-02-003236v1 109/2/683    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Healy, J. Articles by Sinnett, D. Search for Related Content PubMed PubMed Citation Articles by Healy, J. Articles by Sinnett, D. Related Collections Neoplasia Cell Cycle Gene Expression Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  NEOPLASIA Promoter SNPs in G1/S checkpoint regulators and their impact on the susceptibility to childhood leukemia Jasmine Healy1, Hélène Bélanger1, Patrick Beaulieu1, Mathieu Larivière1, Damian Labuda1,2, and Daniel Sinnett1,2, 1 Division of Hematology-Oncology, Research Center, Centre Hospitalo-Universitaire (CHU) Sainte-Justine, Montreal, QC, Canada; 2 Department of Pediatrics, University of Montreal, QC, Canada Mutations leading to the alteration of cell-cycle checkpoint functions are a common feature of most cancers. Because of the highly regulated nature of the cell cycle, it seems likely that variation in gene dosage of key components due to functional regulatory polymorphisms could play an important role in cancer development. Here we provide evidence of the involvement of promoter single-nucleotide polymorphisms (pSNPs) in the cyclin-dependent–kinase inhibitor genes CDKN2A, CDKN2B, CDKN1A, and CDKN1B in the etiology of childhood pre-B acute lymphoblastic leukemia (ALL). A case-control study, conducted in 240 patients with pre-B ALL and 277 healthy controls, combined with a family-based analysis using 135 parental trios, all of French-Canadian origin, were used to evaluate single-site genotypic as well as multilocus haplotypic associations for a total of 10 pSNPs. Using both study designs, we showed evidence of association between variants CDKN2A –222A, CDKN2B –593A, and CDKN1B –1608A, and an increased risk of ALL. These findings suggest that variable expression levels of cell-cycle inhibitor genes CDKN2A, CDKN2B, and CDKN1B due to regulatory polymorphisms could indeed influence the risk of childhood pre-B ALL and contribute to carcinogenesis. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. Healy, M.-H. Roy-Gagnon, and D. Sinnett No evidence for association between TGFB1 promoter SNPs and the risk of childhood pre-B acute lymphoblastic leukemia among French Canadians Haematologica, July 1, 2009; 94(7): 1034 - 1035. [Full Text] [PDF] R. Karchin Next generation tools for the annotation of human SNPs Brief Bioinform, January 1, 2009; 10(1): 35 - 52. [Abstract] [Full Text] [PDF]

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