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Blood, 15 January 2007, Vol. 109, No. 2, pp. 693-702. Prepublished online as a Blood First Edition Paper on September 19, 2006; DOI 10.1182/blood-2006-05-020800. This Article Full Text Full Text (PDF) Supplemental Table and Figure All Versions of this Article: blood-2006-05-020800v1 109/2/693    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Amé-Thomas, P. Articles by Tarte, K. Search for Related Content PubMed PubMed Citation Articles by Amé-Thomas, P. Articles by Tarte, K. Related Collections Stem Cells in Hematology Neoplasia Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  NEOPLASIA Human mesenchymal stem cells isolated from bone marrow and lymphoid organs support tumor B-cell growth: role of stromal cells in follicular lymphoma pathogenesis Patricia Amé-Thomas1,2, Hélène Maby-El Hajjami1, Céline Monvoisin1, Rachel Jean2, Delphine Monnier1,2, Sylvie Caulet-Maugendre3, Thierry Guillaudeux1, Thierry Lamy4, Thierry Fest1,2, and Karin Tarte1,2, 1 Unité Propre de Recherche de l'Enseignement Superieur Equipe d'Accueil (UPRES EA) 3889, Faculté de médecine, Université Rennes 1, Institut Fédératif de Recherche (IFR)140 Génétique Fonctionnelle Agronomie et Santé (GFAS), Rennes, France; 2 Unité Fonctionnelle Suivi Immunologique et Thérapie Cellulaire (UF SITI), Département Hématologie-Immunologie et Thérapie Cellulaire (HITC), Centre Hospitalo-Universitaire (CHU) Pontchaillou, Rennes, France; 3 Laboratoire d'Anatomie Pathologique, CHU Pontchaillou, Rennes, France; 4 Service d'Hématologie Clinique, CHU Pontchaillou, Rennes, France Accumulating evidence indicates that the cellular microenvironment plays a key role in follicular lymphoma (FL) pathogenesis, both within tumor lymph nodes (LNs) and in infiltrated bone marrow where ectopic LN-like reticular cells are integrated within malignant B-cell nodular aggregates. In normal secondary lymphoid organs, specific stromal cell subsets provide a highly specialized microenvironment that supports immune response. In particular, fibroblastic reticular cells (FRCs) mediate immune cell migration, adhesion, and reciprocal interactions. The role of FRCs and their postulated progenitors, that is, bone marrow mesenchymal stem cells (MSCs), in FL remains unexplored. In this study, we investigated the relationships between FRCs and MSCs and their capacity to sustain malignant B-cell growth. Our findings strongly suggest that secondary lymphoid organs contain MSCs able to give rise to adipocytes, chondrocytes, osteoblasts, as well as fully functional B-cell supportive FRCs. In vitro, bone marrow–derived MSCs acquire a complete FRC phenotype in response to a combination of tumor necrosis factor- and lymphotoxin-1ß2. Moreover, MSCs recruit primary FL cells that, in turn, trigger their differentiation into FRCs, making them able to support malignant B-cell survival. Altogether, these new insights into the cross talk between lymphoma cells and their microenvironment could offer original therapeutic strategies. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. Travert, P. Ame-Thomas, C. Pangault, A. Morizot, O. Micheau, G. Semana, T. Lamy, T. Fest, K. Tarte, and T. Guillaudeux CD40 Ligand Protects from TRAIL-Induced Apoptosis in Follicular Lymphomas through NF-{kappa}B Activation and Up-Regulation of c-FLIP and Bcl-xL J. Immunol., July 15, 2008; 181(2): 1001 - 1011. [Abstract] [Full Text] [PDF]

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