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Blood, 1 February 2007, Vol. 109, No. 3, pp. 1069-1076. Prepublished online as a Blood First Edition Paper on September 26, 2006; DOI 10.1182/blood-2006-05-024364. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2006-05-024364v1 109/3/1069    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Pandrea, I. Articles by Silvestri, G. Search for Related Content PubMed PubMed Citation Articles by Pandrea, I. Articles by Silvestri, G. Related Collections Immunobiology Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Paucity of CD4+CCR5+ T cells is a typical feature of natural SIV hosts Ivona Pandrea1, Cristian Apetrei1, Shari Gordon2,3, Joseph Barbercheck1, Jason Dufour1, Rudolf Bohm1, Beth Sumpter3, Pierre Roques4, Preston A. Marx1, Vanessa M. Hirsch5, Amitinder Kaur6, Andrew A. Lackner1, Ronald S. Veazey1, and Guido Silvestri2,3 1 Tulane National Primate Research Center, Covington, LA; 2 Department of Pathology, University of Pennsylvania, Philadelphia, PA; 3 Yerkes National Primate Research Center, Atlanta, GA; 4 Centre International de Recherches Medicales, Franceville, Gabon; 5 Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD; 6 New England Primate Research Center, Southborough, MA In contrast to lentiviral infections of humans and macaques, simian immunodeficiency virus (SIV) infection of natural hosts is nonpathogenic despite high levels of viral replication. However, the mechanisms underlying this absence of disease are unknown. Here we report that natural hosts for SIV infection express remarkably low levels of CCR5 on CD4+ T cells isolated from blood, lymph nodes, and mucosal tissues. Given that this immunologic feature is found in 5 different species of natural SIV hosts (sooty mangabeys, African green monkeys, mandrills, sun-tailed monkeys, and chimpanzees) but is absent in 5 nonnatural/recent hosts (humans, rhesus, pigtail, cynomolgus macaques, and baboons), it may represent a key feature of the coevolution between the virus and its natural hosts that led to a nonpathogenic infection. Beneficial effects of low CCR5 expression on CD4+ T cells may include the reduction of target cells for viral replication and a decreased homing of activated CD4+ T cells to inflamed tissue. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: CCR5 and HIV: the less, the better Mario Roederer and Joseph Mattapallil Blood 2007 109: 854. [Full Text] [PDF] This article has been cited by other articles: T. Gaufin, M. Pattison, R. Gautam, C. Stoulig, J. Dufour, J. MacFarland, D. Mandell, C. Tatum, M. H. Marx, R. M. Ribeiro, et al. Effect of B-Cell Depletion on Viral Replication and Clinical Outcome of Simian Immunodeficiency Virus Infection in a Natural Host J. Virol., October 15, 2009; 83(20): 10347 - 10357. [Abstract] [Full Text] [PDF] Y. M. Mueller, D. H. Do, J. D. Boyer, M. Kader, J. J. Mattapallil, M. G. Lewis, D. B. Weiner, and P. D. Katsikis CD8+ Cell Depletion of SHIV89.6P-Infected Macaques Induces CD4+ T Cell Proliferation that Contributes to Increased Viral Loads J. Immunol., October 15, 2009; 183(8): 5006 - 5012. [Abstract] [Full Text] [PDF] R. Gautam, T. Gaufin, I. Butler, A. Gautam, M. Barnes, D. Mandell, M. Pattison, C. Tatum, J. Macfarland, C. Monjure, et al. Simian Immunodeficiency Virus SIVrcm, a Unique CCR2-Tropic Virus, Selectively Depletes Memory CD4+ T Cells in Pigtailed Macaques through Expanded Coreceptor Usage In Vivo J. Virol., August 15, 2009; 83(16): 7894 - 7908. [Abstract] [Full Text] [PDF] T. Gaufin, R. Gautam, M. Kasheta, R. Ribeiro, E. Ribka, M. Barnes, M. Pattison, C. Tatum, J. MacFarland, D. Montefiori, et al. Limited ability of humoral immune responses in control of viremia during infection with SIVsmmD215 strain Blood, April 30, 2009; 113(18): 4250 - 4261. [Abstract] [Full Text] [PDF] J. F. Camargo, M. P. Quinones, S. Mummidi, S. Srinivas, A. A. Gaitan, K. Begum, F. Jimenez, S. VanCompernolle, D. Unutmaz, S. S. Ahuja, et al. CCR5 Expression Levels Influence NFAT Translocation, IL-2 Production, and Subsequent Signaling Events during T Lymphocyte Activation J. Immunol., January 1, 2009; 182(1): 171 - 182. [Abstract] [Full Text] [PDF] M. E. Dahl, A. Berson, J. Lora, and M. Fuentes A Novel CCR5-Specific Pharmacodynamic Assay in Whole Blood Using Phosphoflow Cytometry Highlights Different Ligand-Dependent Responses but Similar Properties of Antagonists in CD8+ and CD4+ T Lymphocytes J. Pharmacol. Exp. Ther., December 1, 2008; 327(3): 926 - 933. [Abstract] [Full Text] [PDF] R. C. Zahn, M. D. Rett, B. Korioth-Schmitz, Y. Sun, A. P. Buzby, S. Goldstein, C. R. Brown, R. A. Byrum, G. J. Freeman, N. L. Letvin, et al. Simian Immunodeficiency Virus (SIV)-Specific CD8+ T-Cell Responses in Vervet African Green Monkeys Chronically Infected with SIVagm J. Virol., December 1, 2008; 82(23): 11577 - 11588. [Abstract] [Full Text] [PDF] I. Pandrea, R. Onanga, S. Souquiere, A. Mouinga-Ondeme, O. Bourry, M. Makuwa, P. Rouquet, G. Silvestri, F. Simon, P. Roques, et al. Paucity of CD4+ CCR5+ T Cells May Prevent Transmission of Simian Immunodeficiency Virus in Natural Nonhuman Primate Hosts by Breast-Feeding J. Virol., June 1, 2008; 82(11): 5501 - 5509. [Abstract] [Full Text] [PDF] I. Pandrea, R. M. Ribeiro, R. Gautam, T. Gaufin, M. Pattison, M. Barnes, C. Monjure, C. Stoulig, J. Dufour, W. Cyprian, et al. Simian Immunodeficiency Virus SIVagm Dynamics in African Green Monkeys J. Virol., April 1, 2008; 82(7): 3713 - 3724. [Abstract] [Full Text] [PDF] S. N. Gordon, R. M. Dunham, J. C. Engram, J. Estes, Z. Wang, N. R. Klatt, M. Paiardini, I. V. Pandrea, C. Apetrei, D. L. Sodora, et al. Short-Lived Infected Cells Support Virus Replication in Sooty Mangabeys Naturally Infected with Simian Immunodeficiency Virus: Implications for AIDS Pathogenesis J. Virol., April 1, 2008; 82(7): 3725 - 3735. [Abstract] [Full Text] [PDF] V. Monceaux, L. Viollet, F. Petit, M. C. Cumont, G. R. Kaufmann, A. M. Aubertin, B. Hurtrel, G. Silvestri, and J. Estaquier CD4+ CCR5+ T-Cell Dynamics during Simian Immunodeficiency Virus Infection of Chinese Rhesus Macaques J. Virol., December 15, 2007; 81(24): 13865 - 13875. [Abstract] [Full Text] [PDF] S. N. Gordon, N. R. Klatt, S. E. Bosinger, J. M. Brenchley, J. M. Milush, J. C. Engram, R. M. Dunham, M. Paiardini, S. Klucking, A. Danesh, et al. Severe Depletion of Mucosal CD4+ T Cells in AIDS-Free Simian Immunodeficiency Virus-Infected Sooty Mangabeys J. Immunol., September 1, 2007; 179(5): 3026 - 3034. [Abstract] [Full Text] [PDF] I. V. Pandrea, R. Gautam, R. M. Ribeiro, J. M. Brenchley, I. F. Butler, M. Pattison, T. Rasmussen, P. A. Marx, G. Silvestri, A. A. Lackner, et al. Acute Loss of Intestinal CD4+ T Cells Is Not Predictive of Simian Immunodeficiency Virus Virulence J. Immunol., September 1, 2007; 179(5): 3035 - 3046. [Abstract] [Full Text] [PDF] S. Mummidi, L. M. Adams, S. E. VanCompernolle, M. Kalkonde, J. F. Camargo, H. Kulkarni, A. S. Bellinger, G. Bonello, H. Tagoh, S. S. Ahuja, et al. Production of Specific mRNA Transcripts, Usage of an Alternate Promoter, and Octamer-Binding Transcription Factors Influence the Surface Expression Levels of the HIV Coreceptor CCR5 on Primary T Cells J. Immunol., May 1, 2007; 178(9): 5668 - 5681. [Abstract] [Full Text] [PDF]

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