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Blood, 1 February 2007, Vol. 109, No. 3, pp. 1131-1137. Prepublished online as a Blood First Edition Paper on September 19, 2006; DOI 10.1182/blood-2006-05-023770. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2006-05-023770v1 109/3/1131    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Cervantes-Barragan, L. Articles by Ludewig, B. Search for Related Content PubMed PubMed Citation Articles by Cervantes-Barragan, L. Articles by Ludewig, B. Related Collections Immunobiology Phagocytes Chemokines, Cytokines, and Interleukins Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Control of coronavirus infection through plasmacytoid dendritic-cell–derived type I interferon Luisa Cervantes-Barragan1,2, Roland Züst1, Friedemann Weber3, Martin Spiegel3, Karl S. Lang4, Shizuo Akira5, Volker Thiel1, and Burkhard Ludewig1 1 Research Department, Kantonal Hospital St Gallen, St Gallen, Switzerland; 2 Unidad de Investigación Médica en Inmunoquímica, Hospital de Especialidades, Mexico City, Mexico; 3 Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, Freiburg, Germany; 4 Institute of Experimental Immunology, University Hospital, Zurich, Switzerland; 5 Department of Host Defense, Osaka University, Osaka, Japan This study demonstrates a unique and crucial role of plasmacytoid dendritic cells (pDCs) and pDC-derived type I interferons (IFNs) in the pathogenesis of mouse coronavirus infection. pDCs controlled the fast replicating mouse hepatitis virus (MHV) through the immediate production of type I IFNs. Recognition of MHV by pDCs was mediated via TLR7 ensuring a swift IFN- production following encounter with this cytopathic RNA virus. Furthermore, the particular type I IFN response pattern was not restricted to the murine coronavirus, but was also found in infection with the highly cytopathic human severe acute respiratory syndrome (SARS) coronavirus. Taken together, our results suggest that rapid production of type I IFNs by pDCs is essential for the control of potentially lethal coronavirus infections. Abbreviations: MHV, indicates mouse hepatitis virusSARS, severe acute respiratory syndromepDCs, plasmacytoid dendritic cellscDCs, conventional dendritic cells CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: K. Narayanan, C. Huang, K. Lokugamage, W. Kamitani, T. Ikegami, C.-T. K. Tseng, and S. Makino Severe Acute Respiratory Syndrome Coronavirus nsp1 Suppresses Host Gene Expression, Including That of Type I Interferon, in Infected Cells J. Virol., May 1, 2008; 82(9): 4471 - 4479. [Abstract] [Full Text] [PDF] G. Tekes, R. 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