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Blood, 1 February 2007, Vol. 109, No. 3, pp. 1147-1155. Prepublished online as a Blood First Edition Paper on September 28, 2006; DOI 10.1182/blood-2006-02-001339.
IMMUNOBIOLOGY PI3K regulates pleckstrin-2 in T-cell cytoskeletal reorganization1 Medicine, University of Pennsylvania School of Medicine, Philadelphia; 2 Howard Hughes Medical Institute, The Cox Institute, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia; 3 Department of Pathology, Children's Hospital of Philadelphia and the University of Pennsylvania; 4 Pennsylvania Muscle Institute and Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia; and 5 Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia
Pleckstrin-2 is composed of 2 pleckstrin homology (PH) domains and a disheveledEgl-10pleckstrin (DEP) domain. A lipid-binding assay revealed that pleckstrin-2 binds with greatest affinity to D3 and D5 phosphoinositides. Pleckstrin-2 expressed in Jurkat T cells bound to the cellular membrane and enhanced actin-dependent spreading only after stimulation of the T-cell antigen receptor or the integrin
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