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Blood, 1 February 2007, Vol. 109, No. 3, pp. 1165-1173.
Prepublished online as a Blood First Edition Paper on October 12, 2006; DOI 10.1182/blood-2006-05-015354.
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IMMUNOBIOLOGY
Production of interferons by dendritic cells, plasmacytoid cells, natural killer cells, and interferon-producing killer dendritic cells
David Vremec1,
Meredith O'Keeffe2,
Hubertus Hochrein2,
Martina Fuchsberger1,
Irina Caminschi1,
Mireille Lahoud1, and
Ken Shortman1
1 The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia; and
2 the Bavarian Nordic GmbH, Munich, Germany
The capacity of mouse spleen conventional dendritic cells (cDCs) and plasmacytoid dendritic cells (pDCs) to produce interferon- (IFN- ) or IFN- was assessed, and compared with that of natural killer (NK) cells and the recently identified interferon-producing killer dendritic cells (IKDCs), both of which are frequent contaminants in DC preparations. Fully developed cDCs or pDCs, if free of NK cells or IKDCs, showed little capacity for IFN- production. However, an early developmental form of the CD48+ cDC subtype, and the Ly6C Ly49Q pDC subtype, both were able to produce moderate amounts of IFN- , although less than IKDCs. In response to toll-like receptor 9 stimuli, both the Ly6C+ Ly49Q+ and the Ly6C Ly49Q pDC subtypes were effective producers of IFN- . However, IKDCs, which efficiently produced IFN- and showed immediate cytotoxicity on NK target cells, did not produce IFN- un-der these conditions.

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