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Blood, 1 February 2007, Vol. 109, No. 3, pp. 1165-1173. Prepublished online as a Blood First Edition Paper on October 12, 2006; DOI 10.1182/blood-2006-05-015354. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2006-05-015354v1 109/3/1165    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Vremec, D. Articles by Shortman, K. Search for Related Content PubMed PubMed Citation Articles by Vremec, D. Articles by Shortman, K. Related Collections Chemokines, Cytokines, and Interleukins Immunobiology Phagocytes Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Production of interferons by dendritic cells, plasmacytoid cells, natural killer cells, and interferon-producing killer dendritic cells David Vremec1, Meredith O'Keeffe2, Hubertus Hochrein2, Martina Fuchsberger1, Irina Caminschi1, Mireille Lahoud1, and Ken Shortman1 1 The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia; and 2 the Bavarian Nordic GmbH, Munich, Germany The capacity of mouse spleen conventional dendritic cells (cDCs) and plasmacytoid dendritic cells (pDCs) to produce interferon- (IFN-) or IFN- was assessed, and compared with that of natural killer (NK) cells and the recently identified interferon-producing killer dendritic cells (IKDCs), both of which are frequent contaminants in DC preparations. Fully developed cDCs or pDCs, if free of NK cells or IKDCs, showed little capacity for IFN- production. However, an early developmental form of the CD4–8+ cDC subtype, and the Ly6C– Ly49Q– pDC subtype, both were able to produce moderate amounts of IFN-, although less than IKDCs. In response to toll-like receptor 9 stimuli, both the Ly6C+ Ly49Q+ and the Ly6C– Ly49Q– pDC subtypes were effective producers of IFN-. However, IKDCs, which efficiently produced IFN- and showed immediate cytotoxicity on NK target cells, did not produce IFN- un-der these conditions. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C. Chauvin and R. Josien Dendritic Cells as Killers: Mechanistic Aspects and Potential Roles J. Immunol., July 1, 2008; 181(1): 11 - 16. [Abstract] [Full Text] [PDF] G. Mignot, E. Ullrich, M. Bonmort, C. Menard, L. Apetoh, J. Taieb, D. Bosisio, S. Sozzani, M. Ferrantini, J. Schmitz, et al. 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The developmental program of human dendritic cells is operated independently of conventional myeloid and lymphoid pathways Blood, November 15, 2007; 110(10): 3591 - 3660. [Abstract] [Full Text] [PDF] A. L. Blasius, W. Barchet, M. Cella, and M. Colonna Development and function of murine B220+CD11c+NK1.1+ cells identify them as a subset of NK cells J. Exp. Med., October 29, 2007; 204(11): 2561 - 2568. [Abstract] [Full Text] [PDF] I. Caminschi, F. Ahmet, K. Heger, J. Brady, S. L. Nutt, D. Vremec, S. Pietersz, M. H. Lahoud, L. Schofield, D. S. Hansen, et al. Putative IKDCs are functionally and developmentally similar to natural killer cells, but not to dendritic cells J. Exp. Med., October 29, 2007; 204(11): 2579 - 2590. [Abstract] [Full Text] [PDF] C. A.J. Vosshenrich, S. Lesjean-Pottier, M. Hasan, O. Richard-Le Goff, E. Corcuff, O. Mandelboim, and J. P. Di Santo CD11cloB220+ interferon-producing killer dendritic cells are activated natural killer cells J. Exp. 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