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Blood, 1 February 2007, Vol. 109, No. 3, pp. 1174-1181. Prepublished online as a Blood First Edition Paper on October 17, 2006; DOI 10.1182/blood-2006-04-015172. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2006-04-015172v1 109/3/1174    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Wang, X. Articles by Veazey, R. S. Search for Related Content PubMed PubMed Citation Articles by Wang, X. Articles by Veazey, R. S. Related Collections Immunobiology Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Massive infection and loss of CD4+ T cells occurs in the intestinal tract of neonatal rhesus macaques in acute SIV infection Xiaolei Wang1, Terri Rasmussen1, Bapi Pahar1, Bhawna Poonia1, Xavier Alvarez1, Andrew A. Lackner1, and Ronald S. Veazey1 1 Tulane National Primate Research Center, Tulane University School of Medicine, Covington, LA Rapid, profound, and selective depletion of memory CD4+ T cells has now been confirmed to occur in simian immunodeficiency virus (SIV)–infected adult macaques and human immunodeficiency virus (HIV)–infected humans. Within days of infection, marked depletion of memory CD4+ T cells occurs primarily in mucosal tissues, the major reservoir for memory CD4+ T cells in adults. However, HIV infection in neonates often results in higher viral loads and rapid disease progression, despite the paucity of memory CD4+ T cells in the peripheral blood. Here, we examined the immunophenotype of CD4+ T cells in normal and SIV-infected neonatal macaques to determine the distribution of naive and memory T-cell subsets in tissues. We demonstrate that, similar to adults, neonates have abundant memory CD4+ T cells in the intestinal tract and spleen and that these are selectively infected and depleted in primary SIV infection. Within 12 days of SIV infection, activated (CD69+), central memory (CD95+CD28+) CD4+ T cells are marked and persistently depleted in the intestine and other tissues of neonates compared with controls. The results in dicate that "activated" central memory CD4+ T cells are the major target for early SIV infection and CD4+ T cell depletion in neonatal macaques. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: CCR5 and HIV: the less, the better Mario Roederer and Joseph Mattapallil Blood 2007 109: 854. [Full Text] [PDF] This article has been cited by other articles: Z. Hanna, E. Priceputu, P. Chrobak, C. Hu, V. Dugas, M. Goupil, M. Marquis, L. de Repentigny, and P. Jolicoeur Selective Expression of Human Immunodeficiency Virus Nef in Specific Immune Cell Populations of Transgenic Mice Is Associated with Distinct AIDS-Like Phenotypes J. Virol., October 1, 2009; 83(19): 9743 - 9758. [Abstract] [Full Text] [PDF] X. Wang, A. Das, A. A. Lackner, R. S. Veazey, and B. Pahar Intestinal double-positive CD4+CD8+ T cells of neonatal rhesus macaques are proliferating, activated memory cells and primary targets for SIVMAC251 infection Blood, December 15, 2008; 112(13): 4981 - 4990. [Abstract] [Full Text] [PDF] Y. Sun, S. R. Permar, A. P. Buzby, and N. L. Letvin Memory CD4+ T-Lymphocyte Loss and Dysfunction during Primary Simian Immunodeficiency Virus Infection J. Virol., August 1, 2007; 81(15): 8009 - 8015. [Abstract] [Full Text] [PDF]

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