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Blood, 1 March 2007, Vol. 109, No. 5, pp. 2250-2255. Prepublished online as a Blood First Edition Paper on October 19, 2006; DOI 10.1182/blood-2006-07-035022. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2006-07-035022v1 109/5/2250    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Antunes, H. S. Articles by Ferreira, C. G. Search for Related Content PubMed PubMed Citation Articles by Antunes, H. S. Articles by Ferreira, C. G. Related Collections Transplantation Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSPLANTATION Low-power laser in the prevention of induced oral mucositis in bone marrow transplantation patients: a randomized trial Héliton Spíndola Antunes1,5, Alexandre Mello de Azevedo2, Luiz Fernando da Silva Bouzas2, Carlos Alberto Esteves Adão2, Claudia Tereza Pinheiro1, Renato Mayhe1, Lucia Helena Pinheiro2, Renato Azevedo2, Valkiria D'Aiuto de Matos1, Pedro Carvalho Rodrigues3, Isabele Avila Small4, Renato Amaro Zangaro5, and Carlos Gil Ferreira4 1 Section of Dentistry, Instituto Nacional de Câncer (INCA), Rio de Janeiro, Brazil; 2 Bone Marrow Transplant Center (CEMO), INCA, Rio de Janeiro, Brazil; 3 Therapy and Technology Development Section, INCA, Rio de Janeiro, Brazil; 4 Clinical Research Service, INCA, Rio de Janeiro, Brazil; 5 Institute for Research and Development, Universidade do Vale do Paraíba, São Paulo, Brazil We investigated the clinical effects of low-power laser therapy (LPLT) on prevention and reduction of severity of conditioning-induced oral mucositis (OM) for hematopoietic stem cell transplantation (HSCT). We randomized 38 patients who underwent autologous (AT) or allogeneic (AL) HSCT. A diode InGaAlP was used, emitting light at 660 nm, 50 mW, and 4 J/cm2, measured at the fiberoptic end with 0.196 cm2 of section area. The evaluation of OM was done using the Oral Mucositis Assessment Scale (OMAS) and the World Health Organization (WHO) scale. In the LPLT group, 94.7% of patients had an OM grade (WHO) lower than or equal to grade 2, including 63.2% with grade 0 and 1, whereas in the controls group, 31.5% of patients had an OM grade lower than or equal to grade 2 (P < .001). Remarkably, the hazard ratio (HR) for grades 2, 3, and 4 OM was 0.41 (range, 0.22-0.75; P = .002) and for grades 3 and 4 it was 0.07 (range, 0.11-0.53; P < .001). Using OMAS by the calculation of ulcerous area, 5.3% of the laser group presented with ulcers of 9.1 cm2 to 18 cm2, whereas 73.6% of the control group presented with ulcers from 9.1 cm2 to 18 cm2 (P = .003). Our results indicate that the use of upfront LPLT in patients who have undergone HSCT is a powerful instrument in reducing the incidence of OM and is now standard in our center. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

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