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Blood, 15 March 2007, Vol. 109, No. 6, pp. 2339-2345. Prepublished online as a Blood First Edition Paper on November 21, 2006; DOI 10.1182/blood-2006-05-021089. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2006-05-021089v1 109/6/2339    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Cariappa, A. Articles by Pillai, S. Search for Related Content PubMed PubMed Citation Articles by Cariappa, A. Articles by Pillai, S. Related Collections Hematopoiesis and Stem Cells Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMATOPOIESIS Naive recirculating B cells mature simultaneously in the spleen and bone marrow Annaiah Cariappa1, Catharine Chase1, Haoyuan Liu1, Paul Russell1, and Shiv Pillai1 1 Massachusetts General Hospital and Harvard Medical School, Boston We have recently demonstrated that IgDhi B cells can occupy an extravascular perisinusoidal niche in the bone marrow in addition to the well-established follicular niche in conventional secondary lymphoid organs. The spleen has long been considered to be the site at which newly formed B lymphocytes mature into IgDhi naive recirculating B cells, but the existence of mutant mice that have selectively lost mature B cells in the bone marrow prompted an examination of B-cell maturation at this latter site. Following a single pulse of BrdU in intact mice, sequential labeling of more mature B-cell populations in the bone marrow suggested ongoing maturation at this site. Further evidence for B-cell maturation in the bone marrow was obtained from analyses of transitional B cells in splenectomized lymphotoxin -deficient mice that lack all secondary lymphoid organs. In these mice, antibody-secreting cells recognizing multivalent antigens were also observed in the bone marrow following an intravenous microbial challenge. These data suggest that newly formed B cells mature into IgDhi B cells simultaneously in the spleen and the bone marrow and establish in a stringent manner that humoral immune responses can be initiated in situ in the bone marrow. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. Sanyal, R. Fernandez, and S. Levy Enhanced B cell activation in the absence of CD81 Int. Immunol., November 1, 2009; 21(11): 1225 - 1237. [Abstract] [Full Text] [PDF] D. M. Brainard, E. Seung, N. Frahm, A. Cariappa, C. C. Bailey, W. K. Hart, H.-S. Shin, S. F. Brooks, H. L. Knight, Q. Eichbaum, et al. Induction of Robust Cellular and Humoral Virus-Specific Adaptive Immune Responses in Human Immunodeficiency Virus-Infected Humanized BLT Mice J. Virol., July 15, 2009; 83(14): 7305 - 7321. [Abstract] [Full Text] [PDF] A. Cariappa, H. Takematsu, H. Liu, S. Diaz, K. Haider, C. Boboila, G. Kalloo, M. Connole, H. N. Shi, N. Varki, et al. B cell antigen receptor signal strength and peripheral B cell development are regulated by a 9-O-acetyl sialic acid esterase J. Exp. Med., January 16, 2009; 206(1): 125 - 138. [Abstract] [Full Text] [PDF] J. B. Carey, C. S. Moffatt-Blue, L. C. Watson, A. L. Gavin, and A. J. Feeney Repertoire-based selection into the marginal zone compartment during B cell development J. Exp. Med., September 1, 2008; 205(9): 2043 - 2052. [Abstract] [Full Text] [PDF] H. Wasserstrom, J. Bussel, L. C.-L. Lim, and C. Cunningham-Rundles Memory B Cells and Pneumococcal Antibody After Splenectomy J. Immunol., September 1, 2008; 181(5): 3684 - 3689. [Abstract] [Full Text] [PDF] Y. Shimomura, A. Ogawa, M. Kawada, K. Sugimoto, E. Mizoguchi, H.-N. Shi, S. Pillai, A. K. Bhan, and A. Mizoguchi A unique B2 B cell subset in the intestine J. Exp. Med., June 9, 2008; 205(6): 1343 - 1355. [Abstract] [Full Text] [PDF]

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