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Blood, 15 March 2007, Vol. 109, No. 6, pp. 2538-2544. Prepublished online as a Blood First Edition Paper on December 7, 2006; DOI 10.1182/blood-2006-08-038661. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2006-08-038661v1 109/6/2538    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Fernando, K. Articles by Weissman, D. Search for Related Content PubMed PubMed Citation Articles by Fernando, K. Articles by Weissman, D. Related Collections Immunobiology Immunotherapy Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Vaccine-delivered HIV envelope inhibits CD4+ T-cell activation, a mechanism for poor HIV vaccine responses Kathy Fernando1, Haitao Hu1, Houping Ni1, James A. Hoxie2, and Drew Weissman1 1 Division of Infectious Diseases, Department of Medicine, University of Pennsylvania, Philadelphia, PA; 2 Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA The human immunodeficiency virus (HIV) causes impairment of the immune system in part by targeting CD4+ T cells for infection and dysfunction. HIV envelope (Env) present on free virions and infected cells causes dysfunction of uninfected bystander CD4+ T cells via interaction with both CD4 and coreceptors. Env is commonly used as part of a cocktail of HIV antigens in current vaccines. In DNA and viral vector vaccine approaches, antigen-presenting cells (APCs) and non-APCs in the vicinity of the vaccine delivery site and draining lymph node express vaccine-derived antigens. The studies here demonstrate that cell-surface expression of Env on APCs and non-APCs as part of the vaccine action causes an inhibition of antigen-induced CD4+ T-cell activation and proliferation mediated by CD4 binding and suggests a potential mechanism for reduced activity of Env-containing HIV vaccines. Similar studies using a functional Env lacking CD4 binding circumvented suppression, suggesting an alternative and potentially superior approach to HIV vaccine design. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. M. Nyakeriga, C. J. Fichtenbaum, J. Goebel, S. A. Nicolaou, L. Conforti, and C. A. Chougnet Engagement of the CD4 Receptor Affects the Redistribution of Lck to the Immunological Synapse in Primary T Cells: Implications for T-Cell Activation during Human Immunodeficiency Virus Type 1 Infection J. Virol., February 1, 2009; 83(3): 1193 - 1200. [Abstract] [Full Text] [PDF] H. Hu, K. Fernando, H. Ni, and D. Weissman HIV Envelope Suppresses CD4+ T Cell Activation Independent of T Regulatory Cells J. Immunol., April 15, 2008; 180(8): 5593 - 5600. [Abstract] [Full Text] [PDF]

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