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 Blood, 15 March 2007, Vol. 109, No. 6, pp. 2545-2552.
Prepublished online as a Blood First Edition Paper on November 28, 2006; DOI 10.1182/blood-2006-07-037150.

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IMMUNOBIOLOGY

A novel human B cell subpopulation representing the initial germinal center population to express AID

Grant R. Kolar1, Darshna Mehta1, Rosana Pelayo2, and J. Donald Capra1

1 Program in Molecular Immunogenetics and 2 Program in Immunobiology and Cancer, Oklahoma Medical Research Foundation, Oklahoma City, OK

We have identified a novel mature human B-cell subpopulation in the human tonsil that has characteristics of both naive B cells and germinal center B cells including the expression of activation-induced cytidine deaminase (AID), which is essential for the process of immunoglobulin somatic hypermutation and class-switch recombination. These cells are clearly somatically hypermutated, albeit modestly. Their phenotype (IgD+CD38–CD23–FSChiCD71+) is unique and suggests they may be intermediate between both naive and germinal center cells. Morphologically they are also distinct from other B-cell subpopulations. The evidence presented suggests these cells may be the founder cells of the germinal center reaction (a pro-GC cell) and may be the normal counterpart of the mantle cell lymphoma cell.


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