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 Blood, 15 March 2007, Vol. 109, No. 6, pp. 2553-2556.
Prepublished online as a Blood First Edition Paper on November 7, 2006; DOI 10.1182/blood-2006-07-037960.

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IMMUNOBIOLOGY

Brief Report

Impaired Toll-like receptor 8–mediated IL-6 and TNF-{alpha} production in antigen-presenting cells from patients with X-linked agammaglobulinemia

Klára Sochorová1, Rudolf Horváth1, Daniela Rozková1, Jirí Litzman2, Jirina Bartunková1, Anna Sedivá1, and Radek Spísek1

1 Institute of Immunology, Charles University, 2nd Medical School, Prague, Czech Republic; 2 Department of Clinical Immunology and Allergology, Masaryk University, Brno, Czech Republic

The critical role of Bruton tyrosine kinase (Btk) in B cells has been documented by the block of B-cell development in X-linked agammaglobulinemia (XLA). Less is known about Btk function in myeloid cells. Several pieces of evidence indicate that Btk is a component of Toll-like receptor (TLR) signaling. We analyzed whether Btk deficiency in XLA is associated with an impaired dendritic cell (DC) compartment or defective TLR signaling. We analyzed the expression of TLRs 1 to 9 on myeloid DCs generated from XLA patients and evaluated their response to activation by specific TLR agonists. We show that XLA patients have normal numbers of circulating DCs. Btk-deficient DCs have no defect in response to stimulation of TLRs 1/2, 2/6, 3, 4, and 5 but display a profound impairment of IL-6 and TNF-{alpha} production in response to stimulation by TLR-8 cognate agonist, ssRNA. These findings may provide an explanation for the susceptibility to enteroviral infections in XLA patients.


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Bruton tyrosine kinase (Btk): key for signaling via Toll-like receptor 8
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Blood 2007 109: 2273-2274. [Full Text] [PDF]



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