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 Blood, 1 April 2007, Vol. 109, No. 7, pp. 2878-2886.
Prepublished online as a Blood First Edition Paper on December 5, 2006; DOI 10.1182/blood-2006-07-037754.

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IMMUNOBIOLOGY

Interleukin 2 gene transcription is regulated by Ikaros-induced changes in histone acetylation in anergic T cells

Sanmay Bandyopadhyay1, Myrianne Duré1, Monika Paroder1, Noemí Soto-Nieves1, Irene Puga1, and Fernando Macián1

1 Albert Einstein College of Medicine, Department of Pathology, Bronx, NY

In T cells anergy may be evoked by an unbalanced stimulation of the T-cell receptor in the absence of costimulation. Anergic T cells are unresponsive to new antigen receptor engagement and do not produce interleukin 2. We present evidence that anergizing stimuli induce changes in histone acetylation, which mediates transcriptional repression of interleukin 2 expression. In response to calcium signaling, anergic T cells up-regulate the expression of Ikaros, a zinc finger transcription factor essential for lymphoid lineage determination. Ikaros binds to the interleukin 2 promoter where it induces histone deacetylation. Confirming the role of Ikaros in the induction of T-cell anergy, cells with reduced Ikaros activity show defective inactivation in response to an anergizing stimulus. We propose a model in which tolerizing stimuli induce epigenetic changes on the interleukin 2 locus that are responsible for the stable inhibition of the expression of this cytokine in anergic T cells.


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Related Article in Blood Online:

Bringing IL-2 down to earth
Jonathan D. Powell
Blood 2007 109: 2671-2672. [Full Text] [PDF]





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