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Blood, 1 April 2007, Vol. 109, No. 7, pp. 2921-2927. Prepublished online as a Blood First Edition Paper on November 28, 2006; DOI 10.1182/blood-2006-07-037739. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2006-07-037739v1 109/7/2921    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Oh, K. Articles by Min, B. Search for Related Content PubMed PubMed Citation Articles by Oh, K. Articles by Min, B. Related Collections Immunobiology Phagocytes Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Induction of Th2 type immunity in a mouse system reveals a novel immunoregulatory role of basophils Keunhee Oh1, Tao Shen1, Graham Le Gros2, and Booki Min1,3 1 Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, OH; 2 Malaghan Institute of Medical Research, Wellington, New Zealand; 3 Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD While production of cytokines such as IL-12 by activated dendritic cells supports development of Th1 type immunity, a source of early IL-4 that is responsible for Th2 immunity is not well understood. We now show that coculture of basophils could promote a robust Th2 differentiation upon stimulation of naive CD4 T cells primarily via IL-4. Th2 promotion by basophils was also observed even when naive CD4 T cells were stimulated in a Th1-promoting condition or when fully differentiated Th1 phenotype effector CD4 T cells were restimulated. IL-4–deficient basophils failed to induce Th2 differentiation but suppressed Th1 differentiation. It was subsequently revealed that the IL-4–deficient basophils must engage cell-to-cell contact to exert the inhibitory effect on Th1 differentiation. Stimulation of naive CD4 T cells within an in vivo environment of increased basophil generation supported development of Th2 type immunity. Taken together, our results suggest that basophils may provide an important link for the development of Th2 immunity. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: T. Shen, S. Kim, J.-s. Do, L. Wang, C. Lantz, J. F. Urban, G. Le Gros, and B. Min T cell-derived IL-3 plays key role in parasite infection-induced basophil production but is dispensable for in vivo basophil survival Int. Immunol., July 15, 2008; (2008) dxn077v1. [Abstract] [Full Text] [PDF] K. Obata, K. Mukai, Y. Tsujimura, K. Ishiwata, Y. Kawano, Y. Minegishi, N. Watanabe, and H. Karasuyama Basophils are essential initiators of a novel type of chronic allergic inflammation Blood, August 1, 2007; 110(3): 913 - 920. [Abstract] [Full Text] [PDF]

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