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 Blood, 1 April 2007, Vol. 109, No. 7, pp. 2982-2984.
Prepublished online as a Blood First Edition Paper on December 5, 2006; DOI 10.1182/blood-2006-06-022178.

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IMMUNOBIOLOGY

Brief Report

CpG oligodeoxynucleotides allow for effective adoptive T-cell therapy in chronic retroviral infection

Anke R. M. Kraft1, Frank Krux1, Simone Schimmer1, Claes Ohlen2, Philip D. Greenberg3, and Ulf Dittmer1

1 Institute for Virology, University of Duisburg-Essen, Essen, Germany; 2 Science Applications International Corporation (SAIC)–Frederick/National Cancer Institute (NCI), Frederick, MD; 3 Department of Medicine and Immunology, University of Washington, Seattle, WA

Adoptive T-cell therapy in cancer or chronic viral infections is often impeded by the development of functional impairment of the transferred cells. To overcome this therapeutic limitation we combined adoptive transfer of naive, virus-specific CD8+ T cells with immunostimulative CpG oligodeoxynucleotides (ODNs) in mice chronically infected with the Friend retrovirus. The CpG-ODN co-injection prevented the T cells from developing functional defects in IFN{gamma} and granzyme production and degranulation of cytotoxic molecules. Thus, the transferred T cells were able to reduce chronic viral loads when combined with CpG-ODNs. This strategy provides a new approach for developing successful adoptive T-cell therapy against chronic infections.


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S. Balkow, F. Krux, K. Loser, J. U. Becker, S. Grabbe, and U. Dittmer
Friend retrovirus infection of myeloid dendritic cells impairs maturation, prolongs contact to naive T cells, and favors expansion of regulatory T cells
Blood, December 1, 2007; 110(12): 3949 - 3958.
[Abstract] [Full Text] [PDF]


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