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Blood, 1 April 2007, Vol. 109, No. 7, pp. 3050-3059. Prepublished online as a Blood First Edition Paper on November 21, 2006; DOI 10.1182/blood-2006-07-034330. This Article Full Text Full Text (PDF) Supplemental Tables All Versions of this Article: blood-2006-07-034330v1 109/7/3050    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Lim, U. Articles by Lan, Q. Search for Related Content PubMed PubMed Citation Articles by Lim, U. Articles by Lan, Q. Related Collections Clinical Trials and Observations Neoplasia Related Articles in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  NEOPLASIA Gene-nutrient interactions among determinants of folate and one-carbon metabolism on the risk of non-Hodgkin lymphoma: NCI-SEER Case-Control Study Unhee Lim1, Sophia S. Wang1, Patricia Hartge1, Wendy Cozen2, Linda E. Kelemen3, Stephen Chanock4, Scott Davis5, Aaron Blair1, Maryjean Schenk6, Nathaniel Rothman1, and Qing Lan1 1 Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Rockville, MD; 2 Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles; 3 Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN; 4 Core Genotyping Facility, Advanced Technology Center, Division of Cancer Epidemiology and Genetics and Pediatric Oncology Branch, Center for Cancer Research, NCI, NIH, DHHS, Bethesda, MD; 5 Division of Public Health Sciences, Fred Hutchinson Cancer Research Center and Department of Epidemiology, University of Washington, Seattle; 6 Department of Family Medicine, Wayne State University and Karmanos Cancer Institute, Detroit, MI We previously reported a lower risk of non-Hodgkin lymphoma (NHL) associated with high consumption of vitamin B6 and methionine, dietary determinants of one-carbon metabolism. Evidence has linked genetic variants involved in one-carbon metabolism to NHL. We investigated 30 polymorphisms in 18 genes for their main effect on NHL among 1141 incident cases and 949 population-based controls and examined gene-nutrient interactions in a subgroup of 386 cases and 319 controls who provided detailed food-frequency information. Odds ratios (ORs) and 95% confidence intervals (CIs) were adjusted for age, sex, and race. We observed a decreased risk of NHL overall with BHMT Ex8+453A>T and increased risk with CBS Ex13+41C>T, FPGS Ex15-263T>C, and SHMT1 Ex12+138C>T and Ex12+236C>T. Furthermore, significant gene-nutrient interactions limited the protective association comparing high versus low vitamin B6 to FPGS Ex15-263T>C CC (OR = 0.22; 95% CI = 0.10-0.52), MTHFS IVS2-1411T>G TT/TG (OR = 0.54; 95% CI = 0.36-0.81), and MTR Ex26-20A>G AA (OR = 0.55; 95% CI = 0.35-0.86) genotypes, and the protective association of methionine to FTHFD Ex10-40G>T GG (OR = 0.63; 95% CI = 0.44-0.91), MTHFR Ex8-62A>C CC (OR = 0.13; 95% CI = 0.04-0.39), and MTRR Ex5+136T>C TT (OR = 0.67; 95% CI = 0.47-0.97) genotypes. Warranting replication, our finding of gene-nutrient interactions in one-carbon metabolism supports their etiologic involvement in lymphomagenesis. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Articles in Blood Online: Risk of non-Hodgkin lymphoma (NHL) in relation to germline variation in DNA repair and related genes Deirdre A. Hill, Sophia S. Wang, James R. Cerhan, Scott Davis, Wendy Cozen, Richard K. Severson, Patricia Hartge, Sholom Wacholder, Meredith Yeager, Stephen J. Chanock, and Nathaniel Rothman Blood 2006 108: 3161-3167. [Abstract] [Full Text] [PDF] Implication of the folate-methionine metabolism pathways in susceptibility to follicular lymphomas Sidonie Niclot, Quentin Pruvot, Caroline Besson, Daniel Savoy, Elisabeth Macintyre, Gilles Salles, Nicole Brousse, Bruno Varet, Paul Landais, Pierre Taupin, Claudine Junien, and Dominique Baudry-Bluteau Blood 2006 108: 278-285. [Abstract] [Full Text] [PDF] This article has been cited by other articles: L. E. Kelemen, T. A. Sellers, J. M. Schildkraut, J. M. Cunningham, R. A. Vierkant, V. S. Pankratz, Z. S. Fredericksen, M. K. Gadre, D. N. Rider, M. Liebow, et al. Genetic Variation in the One-Carbon Transfer Pathway and Ovarian Cancer Risk Cancer Res., April 1, 2008; 68(7): 2498 - 2506. [Abstract] [Full Text] [PDF] S. Koutros, Y. Zhang, Y. Zhu, S. T. Mayne, S. H. Zahm, T. R. Holford, B. P. Leaderer, P. Boyle, and T. Zheng Nutrients Contributing to One-Carbon Metabolism and Risk of Non-Hodgkin Lymphoma Subtypes Am. J. Epidemiol., February 1, 2008; 167(3): 287 - 294. [Abstract] [Full Text] [PDF] L. R. Goldin and S. L. Slager Familial CLL: Genes and Environment Hematology, January 1, 2007; 2007(1): 339 - 345. [Abstract] [Full Text] [PDF]

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