|
|
Blood, 1 April 2007, Vol. 109, No. 7, pp. 3050-3059.
Prepublished online as a Blood First Edition Paper on November 21, 2006; DOI 10.1182/blood-2006-07-034330.
 Previous Article | Table of Contents | Next Article 
NEOPLASIA
Gene-nutrient interactions among determinants of folate and one-carbon metabolism on the risk of non-Hodgkin lymphoma: NCI-SEER Case-Control Study
Unhee Lim1,
Sophia S. Wang1,
Patricia Hartge1,
Wendy Cozen2,
Linda E. Kelemen3,
Stephen Chanock4,
Scott Davis5,
Aaron Blair1,
Maryjean Schenk6,
Nathaniel Rothman1, and
Qing Lan1
1 Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Rockville, MD;
2 Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles;
3 Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN;
4 Core Genotyping Facility, Advanced Technology Center, Division of Cancer Epidemiology and Genetics and Pediatric Oncology Branch, Center for Cancer Research, NCI, NIH, DHHS, Bethesda, MD;
5 Division of Public Health Sciences, Fred Hutchinson Cancer Research Center and Department of Epidemiology, University of Washington, Seattle;
6 Department of Family Medicine, Wayne State University and Karmanos Cancer Institute, Detroit, MI
We previously reported a lower risk of non-Hodgkin lymphoma (NHL) associated with high consumption of vitamin B6 and methionine, dietary determinants of one-carbon metabolism. Evidence has linked genetic variants involved in one-carbon metabolism to NHL. We investigated 30 polymorphisms in 18 genes for their main effect on NHL among 1141 incident cases and 949 population-based controls and examined gene-nutrient interactions in a subgroup of 386 cases and 319 controls who provided detailed food-frequency information. Odds ratios (ORs) and 95% confidence intervals (CIs) were adjusted for age, sex, and race. We observed a decreased risk of NHL overall with BHMT Ex8+453A>T and increased risk with CBS Ex13+41C>T, FPGS Ex15-263T>C, and SHMT1 Ex12+138C>T and Ex12+236C>T. Furthermore, significant gene-nutrient interactions limited the protective association comparing high versus low vitamin B6 to FPGS Ex15-263T>C CC (OR = 0.22; 95% CI = 0.10-0.52), MTHFS IVS2-1411T>G TT/TG (OR = 0.54; 95% CI = 0.36-0.81), and MTR Ex26-20A>G AA (OR = 0.55; 95% CI = 0.35-0.86) genotypes, and the protective association of methionine to FTHFD Ex10-40G>T GG (OR = 0.63; 95% CI = 0.44-0.91), MTHFR Ex8-62A>C CC (OR = 0.13; 95% CI = 0.04-0.39), and MTRR Ex5+136T>C TT (OR = 0.67; 95% CI = 0.47-0.97) genotypes. Warranting replication, our finding of gene-nutrient interactions in one-carbon metabolism supports their etiologic involvement in lymphomagenesis.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
Related Articles in Blood Online:
-
Risk of non-Hodgkin lymphoma (NHL) in relation to germline variation in DNA repair and related genes
- Deirdre A. Hill, Sophia S. Wang, James R. Cerhan, Scott Davis, Wendy Cozen, Richard K. Severson, Patricia Hartge, Sholom Wacholder, Meredith Yeager, Stephen J. Chanock, and Nathaniel Rothman
Blood 2006 108: 3161-3167.
[Abstract]
[Full Text]
[PDF]
-
Implication of the folate-methionine metabolism pathways in susceptibility to follicular lymphomas
- Sidonie Niclot, Quentin Pruvot, Caroline Besson, Daniel Savoy, Elisabeth Macintyre, Gilles Salles, Nicole Brousse, Bruno Varet, Paul Landais, Pierre Taupin, Claudine Junien, and Dominique Baudry-Bluteau
Blood 2006 108: 278-285.
[Abstract]
[Full Text]
[PDF]
This article has been cited by other articles:
|
|
|
|
 
E. Zintzaras and G. D. Kitsios
Synopsis and Synthesis of Candidate-Gene Association Studies in Chronic Lymphocytic Leukemia: The CUMAGAS-CLL Information System
Am. J. Epidemiol.,
September 15, 2009;
170(6):
671 - 678.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Wang, L. Zhang, R. Moslehi, J. Ma, K. Pan, T. Zhou, W. Liu, L. M. Brown, Y. Hu, D. Pee, et al.
Long-Term Garlic or Micronutrient Supplementation, but Not Anti-Helicobacter pylori Therapy, Increases Serum Folate or Glutathione Without Affecting Serum Vitamin B-12 or Homocysteine in a Rural Chinese Population
J. Nutr.,
January 1, 2009;
139(1):
106 - 112.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. M. Morton, S. S. Wang, W. Cozen, M. S. Linet, N. Chatterjee, S. Davis, R. K. Severson, J. S. Colt, M. A. Vasef, N. Rothman, et al.
Etiologic heterogeneity among non-Hodgkin lymphoma subtypes
Blood,
December 15, 2008;
112(13):
5150 - 5160.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. E. Kelemen, T. A. Sellers, J. M. Schildkraut, J. M. Cunningham, R. A. Vierkant, V. S. Pankratz, Z. S. Fredericksen, M. K. Gadre, D. N. Rider, M. Liebow, et al.
Genetic Variation in the One-Carbon Transfer Pathway and Ovarian Cancer Risk
Cancer Res.,
April 1, 2008;
68(7):
2498 - 2506.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Koutros, Y. Zhang, Y. Zhu, S. T. Mayne, S. H. Zahm, T. R. Holford, B. P. Leaderer, P. Boyle, and T. Zheng
Nutrients Contributing to One-Carbon Metabolism and Risk of Non-Hodgkin Lymphoma Subtypes
Am. J. Epidemiol.,
February 1, 2008;
167(3):
287 - 294.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. R. Goldin and S. L. Slager
Familial CLL: Genes and Environment
Hematology,
January 1, 2007;
2007(1):
339 - 345.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
