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Blood, 1 April 2007, Vol. 109, No. 7, pp. 3076-3079. Prepublished online as a Blood First Edition Paper on November 30, 2006; DOI 10.1182/blood-2006-09-045989. This Article Full Text Full Text (PDF) Supplemental Tables All Versions of this Article: blood-2006-09-045989v1 109/7/3076    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Karube, K. Articles by Ohshima, K. Search for Related Content PubMed PubMed Citation Articles by Karube, K. Articles by Ohshima, K. Related Collections Neoplasia Oncogenes and Tumor Suppressors Brief Reports Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  NEOPLASIA Brief Report CD10–MUM1+ follicular lymphoma lacks BCL2 gene translocation and shows characteristic biologic and clinical features Kennosuke Karube2, Ying Guo1, Junji Suzumiya3, Yasuo Sugita2, Yuko Nomura5, Kohei Yamamoto2, Kei Shimizu2, Shirou Yoshida2, Hideki Komatani2, Morishige Takeshita4, Masahiro Kikuchi4, Naoya Nakamura6, Osamu Takasu2, Fumiko Arakawa2, Hiroyuki Tagawa7, Masao Seto7, and Koichi Ohshima2 1 Department of Pathology, State Key Laboratory of Cancer Biology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shannxi, People's Republic of China; 2 Department of Pathology, School of Medicine, Kurume University, Japan; Departments of3 Internal Medicine 4 Pathology, and 5 Pediatrics, School of Medicine, Fukuoka University, Japan; 6 Department of Pathology, Tokai University School of Medicine, Isehara, Japan; 7 Division of Molecular Medicine and Division of Hematology and Cell Therapy, Aichi Cancer Center Institute, Nagoya, Japan CD10 and MUM1 are representative B cell differentiation markers. Follicular lymphoma (FL) is usually positive for CD10 and negative for MUM1. In this study, however, we compared 22 FLs with peculiar phenotype CD10–MUM1+ with 119 typical CD10+MUM1– FLs. All CD10–MUM1+ FL patients exhibited follicular structure with follicular dendritic meshwork, and a high rate of somatic hypermutation and ongoing mutation, similar to typical FL. However, CD10–MUM1+ FLs were encountered frequently in the elderly compared with CD10+MUM1– typical FLs (67.0 versus 58.7 years, P < .01), showed high grade (grade 3A or 3B) morphology (91% versus 17%, P < .001), diffuse proliferation (59% vs 19%, P < .001), and lacked BCL2/IGH translocation (5% versus 92.5%, P < .001), which is the most characteristic aberration in FL, and 88% showed BCL6 gene abnormalities (translocation or amplification). Our results indicate that CD10–MUM1+ FL is different from typical FL with respect to biologic and clinical features. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: T. Katzenberger, J. Kalla, E. Leich, H. Stocklein, E. Hartmann, S. Barnickel, S. Wessendorf, M. M. Ott, H. K. Muller-Hermelink, A. Rosenwald, et al. A distinctive subtype of t(14;18)-negative nodal follicular non-Hodgkin lymphoma characterized by a predominantly diffuse growth pattern and deletions in the chromosomal region 1p36 Blood, January 29, 2009; 113(5): 1053 - 1061. [Abstract] [Full Text] [PDF] N. A. Johnson and R. D. Gascoyne Gene expression signatures in follicular lymphoma: are they ready for the clinic? Haematologica, July 1, 2008; 93(7): 982 - 987. [Full Text] [PDF]

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