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 Blood, 1 April 2007, Vol. 109, No. 7, pp. 3076-3079.
Prepublished online as a Blood First Edition Paper on November 30, 2006; DOI 10.1182/blood-2006-09-045989.

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NEOPLASIA

Brief Report

CD10–MUM1+ follicular lymphoma lacks BCL2 gene translocation and shows characteristic biologic and clinical features

Kennosuke Karube2, Ying Guo1, Junji Suzumiya3, Yasuo Sugita2, Yuko Nomura5, Kohei Yamamoto2, Kei Shimizu2, Shirou Yoshida2, Hideki Komatani2, Morishige Takeshita4, Masahiro Kikuchi4, Naoya Nakamura6, Osamu Takasu2, Fumiko Arakawa2, Hiroyuki Tagawa7, Masao Seto7, and Koichi Ohshima2

1 Department of Pathology, State Key Laboratory of Cancer Biology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shannxi, People's Republic of China; 2 Department of Pathology, School of Medicine, Kurume University, Japan; Departments of3 Internal Medicine 4 Pathology, and 5 Pediatrics, School of Medicine, Fukuoka University, Japan; 6 Department of Pathology, Tokai University School of Medicine, Isehara, Japan; 7 Division of Molecular Medicine and Division of Hematology and Cell Therapy, Aichi Cancer Center Institute, Nagoya, Japan

CD10 and MUM1 are representative B cell differentiation markers. Follicular lymphoma (FL) is usually positive for CD10 and negative for MUM1. In this study, however, we compared 22 FLs with peculiar phenotype CD10–MUM1+ with 119 typical CD10+MUM1– FLs. All CD10–MUM1+ FL patients exhibited follicular structure with follicular dendritic meshwork, and a high rate of somatic hypermutation and ongoing mutation, similar to typical FL. However, CD10–MUM1+ FLs were encountered frequently in the elderly compared with CD10+MUM1– typical FLs (67.0 versus 58.7 years, P < .01), showed high grade (grade 3A or 3B) morphology (91% versus 17%, P < .001), diffuse proliferation (59% vs 19%, P < .001), and lacked BCL2/IGH translocation (5% versus 92.5%, P < .001), which is the most characteristic aberration in FL, and 88% showed BCL6 gene abnormalities (translocation or amplification). Our results indicate that CD10–MUM1+ FL is different from typical FL with respect to biologic and clinical features.


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N. A. Johnson and R. D. Gascoyne
Gene expression signatures in follicular lymphoma: are they ready for the clinic?
Haematologica, July 1, 2008; 93(7): 982 - 987.
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