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 Blood, 1 April 2007, Vol. 109, No. 7, pp. 3080-3083.
Prepublished online as a Blood First Edition Paper on December 14, 2006; DOI 10.1182/blood-2006-06-031096.

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NEOPLASIA

Brief Report

Connective tissue growth factor (CTGF) expression and outcome in adult patients with acute lymphoblastic leukemia

Olga Sala-Torra1, Holly M. Gundacker2, Derek L. Stirewalt1, Paula A. Ladne1, Era L. Pogosova-Agadjanyan1, Marilyn L. Slovak3, Cheryl L. Willman4, Shelly Heimfeld1, David H. Boldt5, and Jerald P. Radich1

1 Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; 2 Statistical Center, Southwest Oncology Group, Seattle, WA; 3 Division of Pathology, City of Hope National Medical Center, Duarte, CA; 4 Department of Pathology, University of New Mexico School of Medicine, Albuquerque; 5 Medicine/Hematology University of Texas, Health Science Center at San Antonio

We compared the gene expression profile of adult acute lymphoblastic leukemia (ALL) to normal hematopoietic and non-ALL samples using oligonucleotide arrays. Connective tissue growth factor (CTGF) was the highest overexpressed gene in B-cell ALL compared with the other groups, and displayed heterogeneous expression, suggesting it might have prognostic relevance. CTGF expression was examined by quantitative reverse transcriptase–polymerase chain reaction (QRT-PCR) on 79 adult ALL specimens. CTGF expression levels were significantly increased in ALL cases with B-lineage (P < .001), unfavorable cytogenetics (P < .001), and blasts expressing CD34 (P < .001). In a multivariate proportional hazards model, higher CTGF expression levels corresponded to worsening of overall survival (OS; hazard ratio 1.36, for each 10-fold increase in expression; P = .019). Further studies are ongoing to confirm the prognostic value of CTGF expression in ALL and to investigate its role in normal and abnormal lymphocyte biology.


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V. Pullarkat, M. L. Slovak, K. J. Kopecky, S. J. Forman, and F. R. Appelbaum
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