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Blood, 1 April 2007, Vol. 109, No. 7, pp. 3115-3123. Prepublished online as a Blood First Edition Paper on December 5, 2006; DOI 10.1182/blood-2006-04-016410. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2006-04-016410v1 109/7/3115    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Chen, B. J. Articles by Chao, N. J. Search for Related Content PubMed PubMed Citation Articles by Chen, B. J. Articles by Chao, N. J. Related Collections Immunobiology Transplantation Social Bookmarking                   What's this?  Previous Article  |  Table of Contents TRANSPLANTATION Inability of memory T cells to induce graft-versus-host disease is a result of an abortive alloresponse Benny J. Chen1, Divino Deoliveira1, Xiuyu Cui1, Ngocdiep T. Le1, Jessica Son1, John F. Whitesides2, and Nelson J. Chao1 1 Division of Cellular Therapy/Bone Marrow Transplantation, 2 Human Vaccine Institute, Department of Medicine and Immunology, Duke University Medical Center, Durham, NC Several groups, including our own, have independently demonstrated that effector memory T cells from non–alloantigen-primed donors do not cause graft-versus-host disease (GVHD). In the current study, we further investigated whether this approach could be extended to all memory T cells, and we studied the underlying mechanisms. Neither total memory T cells nor purified central memory T cells were able to induce GVHD. Memory T cells were at least 3-log less potent than bulk T cells in mediating GVHD. As expected, memory T cells failed to elicit cytotoxicity and proliferated poorly against alloantigens in standard 5-day mixed-lymphocyte cultures. However, the proliferative responses of memory T cells were more comparable with those of bulk and naive T cells when the culture time was shortened. Moreover, the frequencies of IL-2–secreting cells measured by 42-hour enzyme-linked immunosorbent spot (ELISPOT) assay were similar among naive, memory, and bulk T cells. These data indicated that memory T cells are able to respond to alloantigens initially but fail to develop to full potential. The abortive immune response, which was mediated by non–alloantigen-specific memory T cells in response to alloantigens, may explain why memory T cells from unprimed and non–alloantigen-primed donors could not induce GVHD. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: H. Zheng, C. Matte-Martone, D. Jain, J. McNiff, and W. D. Shlomchik Central Memory CD8+ T Cells Induce Graft-versus-Host Disease and Mediate Graft-versus-Leukemia J. Immunol., May 15, 2009; 182(10): 5938 - 5948. [Abstract] [Full Text] [PDF] S. Kaneko, S. Mastaglio, A. Bondanza, M. Ponzoni, F. Sanvito, L. Aldrighetti, M. Radrizzani, S. La Seta-Catamancio, E. Provasi, A. Mondino, et al. IL-7 and IL-15 allow the generation of suicide gene-modified alloreactive self-renewing central memory human T lymphocytes Blood, January 29, 2009; 113(5): 1006 - 1015. [Abstract] [Full Text] [PDF] S. Dutt, D. Tseng, J. Ermann, T. I. George, Y. P. Liu, C. R. Davis, C. G. Fathman, and S. Strober Naive and Memory T Cells Induce Different Types of Graft-versus-Host Disease J. Immunol., November 15, 2007; 179(10): 6547 - 6554. [Abstract] [Full Text] [PDF]

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