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Blood, 15 April 2007, Vol. 109, No. 8, pp. 3279-3283. Prepublished online as a Blood First Edition Paper on December 7, 2006; DOI 10.1182/blood-2006-08-040709. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2006-08-040709v1 109/8/3279    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Schurgers, L. J. Articles by Vermeer, C. Search for Related Content PubMed PubMed Citation Articles by Schurgers, L. J. Articles by Vermeer, C. Related Collections Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Vitamin K–containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7 Leon J. Schurgers1, Kirsten J. F. Teunissen1, Karly Hamulyák2, Marjo H. J. Knapen1, Hogne Vik3, and Cees Vermeer1 1 VitaK & Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht, The Netherlands; 2 Department of Hematology, University Hospital Maastricht, The Netherlands; 3 NattoPharma ASA, Oslo, Norway Vitamin K is a cofactor in the production of blood coagulation factors (in the liver), osteocalcin (in bone), and matrix Gla protein (cartilage and vessel wall). Accumulating evidence suggests that for optimal bone and vascular health, relatively high intakes of vitamin K are required. The synthetic short-chain vitamin K1 is commonly used in food supplements, but recently the natural long-chain menaquinone-7 (MK-7) has also become available as an over-the-counter (OTC) supplement. The purpose of this paper was to compare in healthy volunteers the absorption and efficacy of K1 and MK-7. Serum vitamin K species were used as a marker for absorption and osteocalcin carboxylation as a marker for activity. Both K1 and MK-7 were absorbed well, with peak serum concentrations at 4 hours after intake. A major difference between the 2 vitamin K species is the very long half-life time of MK-7, resulting in much more stable serum levels, and accumulation of MK-7 to higher levels (7- to 8-fold) during prolonged intake. MK-7 induced more complete carboxylation of osteocalcin, and hematologists should be aware that preparations supplying 50 µg/d or more of MK-7 may interfere with oral anticoagulant treatment in a clinically relevant way. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. C McCann and B. N Ames Vitamin K, an example of triage theory: is micronutrient inadequacy linked to diseases of aging? Am. J. Clinical Nutrition, October 1, 2009; 90(4): 889 - 907. [Abstract] [Full Text] [PDF] M. C. de Assis, E. R. Rabelo, C. W. Avila, C. A. Polanczyk, and L. E. Rohde Improved Oral Anticoagulation After a Dietary Vitamin K-Guided Strategy: A Randomized Controlled Trial Circulation, September 22, 2009; 120(12): 1115 - 1122. [Abstract] [Full Text] [PDF] X. Fu, X.-D. Wang, H. Mernitz, R. Wallin, M. K. Shea, and S. L. Booth 9-Cis Retinoic Acid Reduces 1{alpha},25-Dihydroxycholecalciferol-Induced Renal Calcification by Altering Vitamin K-Dependent {gamma}-Carboxylation of Matrix {gamma}-Carboxyglutamic Acid Protein in A/J Male Mice J. Nutr., December 1, 2008; 138(12): 2337 - 2341. [Abstract] [Full Text] [PDF] J. Danziger Vitamin K-dependent Proteins, Warfarin, and Vascular Calcification Clin. J. Am. Soc. Nephrol., September 1, 2008; 3(5): 1504 - 1510. [Abstract] [Full Text] [PDF]

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