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Blood, 15 April 2007, Vol. 109, No. 8, pp. 3496-3499. Prepublished online as a Blood First Edition Paper on December 27, 2006; DOI 10.1182/blood-2006-07-036012. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2006-07-036012v1 109/8/3496    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Picard, S. Articles by Mahon, F.-X. Search for Related Content PubMed PubMed Citation Articles by Picard, S. Articles by Mahon, F.-X. Related Collections Oncogenes and Tumor Suppressors Brief Reports Clinical Trials and Observations Related Articles in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  NEOPLASIA Brief Report Trough imatinib plasma levels are associated with both cytogenetic and molecular responses to standard-dose imatinib in chronic myeloid leukemia Stephane Picard1,2,3, Karine Titier1,2,3, Gabriel Etienne4, Emmanuelle Teilhet1,2,3, Dominique Ducint1,2,3, Marie-Agnes Bernard1, Regis Lassalle1, Gerald Marit2,5,6, Josy Reiffers4, Bernard Begaud1,2,3, Nicholas Moore1,2,3, Mathieu Molimard1,2,3, and Francois-Xavier Mahon2,5,6 1 Department of Clinical Pharmacology and Toxicology, Centre Hospitalier Universitaire (CHU) de Bordeaux, Bordeaux, France; 2 University Victor Ségalen Bordeaux 2, Bordeaux, France; 3 Institut National de la Santé et de la Recherche Médicale (INSERM) U657, Bordeaux, France; 4 Department of Hematology, the Institut Bergonié, Regional Cancer Center, Bordeaux, France; 5 Department of Hematology and Blood Diseases, CHU de Bordeaux, Bordeaux, France; 6 INSERM E217, Bordeaux, France Using high-performance liquid chromatography–tandem mass spectrometry, we assessed trough imatinib plasma levels in 68 patients with chronic myeloid leukemia (CML) who responded or not to standard-dose imatinib, after at least 12 months' treatment. Mean trough imatinib plasma levels were significantly higher in the group with complete cytogenetic response (56 patients) than in the group without (12 patients; P = .03) and higher in the group with major molecular response (MMR) than in the group without (34 patients [1452 ± 649 ng/mL] versus 34 patients [869 ± 427 ng/mL]; P < .001). Regarding trough imatinib plasma levels and their discrimination potential for MMR, the area under receiver operating characteristic curve was 0.775, with best sensitivity (77%) and specificity (71%) at a plasma threshold of 1002 ng/mL. Therefore, monitoring of imatinib plasma levels could be very useful for the management of patients with CML or should at least be checked in the case of treatment failure or suboptimal response. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Articles in Blood Online: Therapeutic drug monitoring in CML patients on imatinib Carolyn Blasdel, Merrill J. Egorin, Theodore F. Lagattuta, Brian J. Druker, and Michael W. Deininger Blood 2007 110: 1699-1701. [Full Text] [PDF] Use of therapeutic drug monitoring in CML patients on imatinib François-Xavier Mahon, Stéphane Picard, Gerald Marit, Philip Robinson, and Mathieu Molimard Blood 2007 110: 1701. [Full Text] [PDF] This article has been cited by other articles: G. D. Demetri, Y. Wang, E. Wehrle, A. Racine, Z. Nikolova, C. D. Blanke, H. Joensuu, and M. von Mehren Imatinib Plasma Levels Are Correlated With Clinical Benefit in Patients With Unresectable/Metastatic Gastrointestinal Stromal Tumors J. Clin. Oncol., July 1, 2009; 27(19): 3141 - 3147. [Abstract] [Full Text] [PDF] L. Noens, M.-A. van Lierde, R. De Bock, G. Verhoef, P. Zachee, Z. Berneman, P. Martiat, P. Mineur, K. Van Eygen, K. MacDonald, et al. Prevalence, determinants, and outcomes of nonadherence to imatinib therapy in patients with chronic myeloid leukemia: the ADAGIO study Blood, May 28, 2009; 113(22): 5401 - 5411. 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