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 Blood, 1 May 2007, Vol. 109, No. 9, pp. 3649-3657.
Prepublished online as a Blood First Edition Paper on December 29, 2006; DOI 10.1182/blood-2006-01-035717.

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CHEMOKINES, CYTOKINES, AND INTERLEUKINS

Trapping and apoptosis of novel subsets of memory T lymphocytes expressing CCR6 in the spleen of HIV-infected patients

Cédric Lécureuil1, Béhazine Combadière1, Elodie Mazoyer1, Olivia Bonduelle1, Assia Samri1, Brigitte Autran1, Patrice Debré1, and Christophe Combadière1

1 Institut National de la Santé et de la Recherche Médicale (INSERM U543), Assistance Publique–Hôpitaux de Paris (AP-HP), Université Pierre et Marie Curie–Paris 6, Faculté de Médecine, Paris, France

CCR6, a homeostatic chemokine receptor, is shown here to characterize subsets of both central and effector memory T cells that secrete high levels of IL-2 and TNF-{alpha} in response to polyclonal and antigen-specific stimulation. CCR6+ T lymphocytes disappeared dramatically from the peripheral blood of HIV-infected patients as HIV disease progressed. The capacity of CD4+CCR6+ to secrete multiple cytokines remained intact among HIV-infected long-term nonprogressors but was partially lost from subjects with standard disease progression. CCR6+ T lymphocytes, regardless of their CCR7 expression, accumulated in the spleen of HIV-infected patients, where they died by apoptosis. Assessment of CCR6 expression allowed us to describe novel memory T-cell subpopulations capable of high cytokine production and provided evidence of a pathologic CCR6-dependent pathway of memory T-cell homing that may participate in the loss of memory response against infections.


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