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Blood, 1 May 2007, Vol. 109, No. 9, pp. 3749-3756. Prepublished online as a Blood First Edition Paper on January 18, 2007; DOI 10.1182/blood-2006-08-041582. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2006-08-041582v1 109/9/3749    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Kunisawa, J. Articles by Kiyono, H. Search for Related Content PubMed PubMed Citation Articles by Kunisawa, J. Articles by Kiyono, H. Related Collections Immunobiology Signal Transduction Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Sphingosine 1-phosphate regulates peritoneal B-cell trafficking for subsequent intestinal IgA production Jun Kunisawa1, Yosuke Kurashima1, Masashi Gohda1, Morio Higuchi1, Izumi Ishikawa1, Fumi Miura1, Ikuko Ogahara1, and Hiroshi Kiyono1 1 Division of Mucosal Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, and Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Corporation (JST), Tokyo, Japan Sphingosine 1-phosphate (S1P) is known to play a pivotal role in the regulation of lymphocyte emigration from organized lymphoid tissues such as the peripheral lymph nodes and thymus, but its immunologic role in unorganized and diffused tissues remains to be elucidated. Here we show that the trafficking of peritoneal B cells is principally regulated by S1P. All peritoneal B cells including B1a, B1b, and B2 B cells express comparable levels of the type 1 S1P receptor. Thus, treatment with FTY720, an S1P receptor modulator, caused the rapid disappearance of peritoneal B cells by inhibiting both their emigration from parathymic lymph nodes and their recirculation from the blood into the peritoneal cavity without affecting their progenitor populations. These changes did not affect natural plasma antibody production or phosphorylcholine (PC)–specific antibody production in serum after peritoneal immunization with heat-killed Streptococcal pneumoniae (R36A). However, FTY720 dramatically reduced peritoneal B cell-derived natural intestinal secretory IgA production without affecting the expression of J-chain and polyimmunoglobulin receptors. Additionally, FTY720 impaired the generation of PC-specific fecal IgA responses after oral immunization with R36A. These findings point to a pivotal role for S1P in connecting peritoneal B cells with intestinal B-cell immunity. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. Kunisawa, M. Gohda, Y. Kurashima, I. Ishikawa, M. Higuchi, and H. Kiyono Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NF{kappa}B-inducing kinase in stromal cells Blood, May 1, 2008; 111(9): 4646 - 4652. [Abstract] [Full Text] [PDF] M. Gohda, J. Kunisawa, F. Miura, Y. Kagiyama, Y. Kurashima, M. Higuchi, I. Ishikawa, I. Ogahara, and H. Kiyono Sphingosine 1-Phosphate Regulates the Egress of IgA Plasmablasts from Peyer's Patches for Intestinal IgA Responses J. Immunol., April 15, 2008; 180(8): 5335 - 5343. [Abstract] [Full Text] [PDF] W.-Q. Lai, H. H. Goh, Z. Bao, W. S. F. Wong, A. J. Melendez, and B. P. Leung The Role of Sphingosine Kinase in a Murine Model of Allergic Asthma J. Immunol., March 15, 2008; 180(6): 4323 - 4329. [Abstract] [Full Text] [PDF] S. Berberich, S. Dahne, A. Schippers, T. Peters, W. Muller, E. Kremmer, R. Forster, and O. Pabst Differential Molecular and Anatomical Basis for B Cell Migration into the Peritoneal Cavity and Omental Milky Spots J. Immunol., February 15, 2008; 180(4): 2196 - 2203. [Abstract] [Full Text] [PDF] J. Kunisawa, Y. Kurashima, M. Higuchi, M. Gohda, I. Ishikawa, I. Ogahara, N. Kim, M. Shimizu, and H. Kiyono Sphingosine 1-phosphate dependence in the regulation of lymphocyte trafficking to the gut epithelium J. Exp. Med., October 1, 2007; 204(10): 2335 - 2348. [Abstract] [Full Text] [PDF] Y. Kurashima, J. Kunisawa, M. Higuchi, M. Gohda, I. Ishikawa, N. Takayama, M. Shimizu, and H. Kiyono Sphingosine 1-Phosphate-Mediated Trafficking of Pathogenic Th2 and Mast Cells for the Control of Food Allergy J. Immunol., August 1, 2007; 179(3): 1577 - 1585. [Abstract] [Full Text] [PDF] S. Berberich, R. Forster, and O. Pabst The peritoneal micromilieu commits B cells to home to body cavities and the small intestine Blood, June 1, 2007; 109(11): 4627 - 4634. [Abstract] [Full Text] [PDF]

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