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Blood, 1 May 2007, Vol. 109, No. 9, pp. 4023-4027. Prepublished online as a Blood First Edition Paper on January 23, 2007; DOI 10.1182/blood-2006-01-031781. This Article Full Text Full Text (PDF) Supplemental Figures All Versions of this Article: blood-2006-01-031781v1 109/9/4023    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Asou, N. Articles by Osato, M. Search for Related Content PubMed PubMed Citation Articles by Asou, N. Articles by Osato, M. Related Collections Neoplasia Free Research Articles Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  NEOPLASIA Brief Report Concurrent transcriptional deregulation of AML1/RUNX1 and GATA factors by the AML1-TRPS1 chimeric gene in t(8;21)(q24;q22) acute myeloid leukemia Norio Asou1, Masatoshi Yanagida2,4, Liqun Huang2, Masayuki Yamamoto5, Katsuya Shigesada4, Hiroaki Mitsuya1, Yoshiaki Ito2,3, and Motomi Osato2,3 1 Department of Hematology, Kumamoto University School of Medicine, Kumamoto, Japan; 2 Institute of Molecular and Cell Biology, Singapore; 3 Oncology Research Institute, National University of Singapore, Singapore; 4 Institute for Virus Research, Kyoto University, Kyoto, Japan; 5 Institute of Basic Medical Science and Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Ibaraki, Japan The Runt domain transcription factor AML1/RUNX1 is essential for the generation of hematopoietic stem cells and is the most frequent target of chromosomal translocations associated with leukemia. Here, we present a new AML1 translocation found in a patient with acute myeloid leukemia M4 with t(8;21)(q24;q22) at the time of relapse. This translocation generated an in-frame chimeric gene consisting of the N-terminal portion of AML1, retaining the Runt domain, fused to the entire length of TRPS1 on the C-terminus. TRPS1 encodes a putative multitype zinc finger (ZF) protein containing 9 C2H2 type ZFs and 1 GATA type ZF. AML1-TRPS1 stimulated proliferation of hematopoietic colony-forming cells and repressed the transcriptional activity of AML1 and GATA-1 by 2 different mechanisms: competition at their cognate DNA-binding sites and physical sequestrations of AML1 and GATA-1, suggesting that simultaneous deregulation of AML1 and GATA factors constitutes a basis for leukemogenesis. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: E. DE BRAEKELEER, C. FEREC, and M. DE BRAEKELEER RUNX1 Translocations in Malignant Hemopathies Anticancer Res, April 1, 2009; 29(4): 1031 - 1037. [Abstract] [Full Text] [PDF] H.-J. Wee, D. C.-C. Voon, S.-C. Bae, and Y. Ito PEBP2-{beta}/CBF-{beta}-dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesis Blood, November 1, 2008; 112(9): 3777 - 3787. [Abstract] [Full Text] [PDF]

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