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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by WEISBERGER, A. S. Articles by SUHRLAND, L. G. Search for Related Content PubMed PubMed Citation Articles by WEISBERGER, A. S. Articles by SUHRLAND, L. G. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1956, Vol. 11, No. 1, pp. 11-18. © 1956 American Society of Hematology, Inc. Studies on Analogues of L-Cysteine and L-Cystine II. The Effect of Selenium Cystine on Murphy Lymphosarcoma Tumor Cells in the Rat AUSTIN S. WEISBERGER 1 and LEIF G. SUHRLAND 1 1 Department of Medicine, University Hospitals and The School of Medicine, Western Reserve University, Cleveland, Ohio. Selenium cystine decreases the incorporation of S35 L-cystine by rat Murphy lymphosarcoma tumor cells both in vitro and in vivo. Selenium cystine also decreases the growth of the tumor in the intact animal. Benzyl selenium cysteine does not inhibit the incorporation of S35 L-cystine by Murphy lymphosarcoma tumor cells in vitro nor does it affect tumor growth in the intact animal. Thus the ability of selenium cystine to decrease the influx of S35 L-cystine into tumor cells in vitro is associated with the ability of this compound to inhibit tumor growth in the intact animal. Furthermore, the inhibitory effect of selenium cystine is not due solely to the presence of selenium within the molecule but is related to its structural identity with cystine. The data are further suggestive of the importance of SH compounds in the growth of malignant cells. Submitted on July 1, 1955 Accepted on August 30, 1955 CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: N. V. Gopee, V. J. Johnson, and R. P. Sharma Sodium Selenite-Induced Apoptosis in Murine B-Lymphoma Cells Is Associated with Inhibition of Protein Kinase C-{delta}, Nuclear Factor {kappa}B, and Inhibitor of Apoptosis Protein Toxicol. Sci., April 1, 2004; 78(2): 204 - 214. [Abstract] [Full Text] [PDF]

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