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Blood, 1 July 2007, Vol. 110, No. 1, pp. 18-28. Prepublished online as a Blood First Edition Paper on March 6, 2007; DOI 10.1182/blood-2006-09-018069. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2006-09-018069v1 110/1/18    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Lamikanra, A. A. Articles by Roberts, D. J. Search for Related Content PubMed PubMed Citation Articles by Lamikanra, A. A. Articles by Roberts, D. J. Related Collections Red Cells Free Research Articles Review Articles Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  REVIEW IN TRANSLATIONAL HEMATOLOGY Malarial anemia: of mice and men Abigail A. Lamikanra1, Douglas Brown2, Alexandre Potocnik2, Climent Casals-Pascual1,3, Jean Langhorne2, and David J. Roberts1 1 Nuffield Department of Clinical Laboratory Sciences and National Blood Service Oxford Centre, John Radcliffe Hospital, Oxford, United Kingdom; 2 National Institute for Medical Research, The Ridgeway, London, United Kingdom; 3 Medical Research Council Laboratory, Atlantic Road, Fajara, Gambia Severe malaria is manifest by a variety of clinical syndromes dependent on properties of both the host and the parasite. In young infants, severe malarial anemia (SMA) is the most common syndrome of severe disease and contributes substantially to the considerable mortality and morbidity from malaria. There is now growing evidence, from both human and mouse studies of malaria, to show that anemia is due not only to increased hemolysis of infected and clearance of uninfected red blood cells (RBCs) but also to an inability of the infected host to produce an adequate erythroid response. In this review, we will summarize the recent clinical and experimental studies of malaria to highlight similarities and differences in human and mouse pathology that result in anemia and so inform the use of mouse models in the study of severe malarial anemia in humans. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C. C. Keller, C. Ouma, Y. Ouma, G. A. Awandare, G. C. Davenport, T. Were, J. B. Hittner, J. M. Vulule, J. M. Ong'echa, and D. J. Perkins Suppression of a Novel Hematopoietic Mediator in Children with Severe Malarial Anemia Infect. Immun., September 1, 2009; 77(9): 3864 - 3871. [Abstract] [Full Text] [PDF] F. Scheuplein, N. Schwarz, S. Adriouch, C. Krebs, P. Bannas, B. Rissiek, M. Seman, F. Haag, and F. Koch-Nolte NAD+ and ATP Released from Injured Cells Induce P2X7-Dependent Shedding of CD62L and Externalization of Phosphatidylserine by Murine T Cells J. Immunol., March 1, 2009; 182(5): 2898 - 2908. [Abstract] [Full Text] [PDF] N. Thawani, M. Tam, and M. M. Stevenson STAT6-mediated suppression of erythropoiesis in an experimental model of malarial anemia Haematologica, February 1, 2009; 94(2): 195 - 204. [Abstract] [Full Text] [PDF] M. S. Oakley, T. F. McCutchan, V. Anantharaman, J. M. Ward, L. Faucette, C. Erexson, B. Mahajan, H. Zheng, V. Majam, L. Aravind, et al. Host Biomarkers and Biological Pathways That Are Associated with the Expression of Experimental Cerebral Malaria in Mice Infect. Immun., October 1, 2008; 76(10): 4518 - 4529. [Abstract] [Full Text] [PDF] R. Kobbe, N. Schreiber, J. May, and T. Jacobs Simvastatin Treatment Shows No Effect on the Incidence of Cerebral Malaria or Parasitemia during Experimental Malaria Antimicrob. Agents Chemother., April 1, 2008; 52(4): 1583 - 1584. [Full Text] [PDF]

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