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Blood, 15 November 2007, Vol. 110, No. 10, pp. 3624-3626. Prepublished online as a Blood First Edition Paper on August 21, 2007; DOI 10.1182/blood-2007-05-093419. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2007-05-093419v1 110/10/3624    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Menzel, S. Articles by Thein, S. L. Search for Related Content PubMed PubMed Citation Articles by Menzel, S. Articles by Thein, S. L. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMATOPOIESIS Brief Report The HBS1L-MYB intergenic region on chromosome 6q23.3 influences erythrocyte, platelet, and monocyte counts in humans Stephan Menzel1, Jie Jiang1, Nicholas Silver1, Joy Gallagher2, Juliette Cunningham1, Gabriela Surdulescu3, Mark Lathrop4, Martin Farrall5, Tim D. Spector3, and Swee Lay Thein1,2 1 King's College London School of Medicine, Division of Gene and Cell Based Therapy, London, United Kingdom; 2 King's College Hospital, Department of Haematological Medicine, London, United Kingdom; 3 King's College London School of Medicine, Division of Genetics and Molecular Medicine, London, United Kingdom; 4 Centre National de Génotypage, Institut Génomique, Commissariat à l'Energie Atomique, Evry, France; 5 Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom Common sequence variants situated between the HBS1L and MYB genes on chromosome 6q23.3 (HMIP) influence the proportion of F cells (erythrocytes that carry measurable amounts of fetal hemoglobin). Since the physiological processes underlying the F-cell variability are thought to be linked to kinetics of erythrocyte maturation and differentiation, we have investigated the influence of the HMIP locus on other hematologic parameters. Here we show a significant impact of HMIP variability on several types of peripheral blood cells: erythrocyte, platelet, and monocyte counts as well as erythrocyte volume and hemoglobin content in healthy individuals of European ancestry. These results support the notion that changes of F-cell abundance can be an indicator of more general shifts in hematopoietic patterns in humans. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. L. Thein, S. Menzel, M. Lathrop, and C. Garner Control of fetal hemoglobin: new insights emerging from genomics and clinical implications Hum. Mol. Genet., October 15, 2009; 18(R2): R216 - R223. [Abstract] [Full Text] [PDF] K. Wahlberg, J. Jiang, H. Rooks, K. Jawaid, F. Matsuda, M. Yamaguchi, M. Lathrop, S. L. Thein, and S. Best The HBS1L-MYB intergenic interval associated with elevated HbF levels shows characteristics of a distal regulatory region in erythroid cells Blood, August 6, 2009; 114(6): 1254 - 1262. [Abstract] [Full Text] [PDF] G. Lettre, V. G. Sankaran, M. A. C. Bezerra, A. S. Araujo, M. Uda, S. Sanna, A. Cao, D. Schlessinger, F. F. Costa, J. N. Hirschhorn, et al. From the Cover: DNA polymorphisms at the BCL11A, HBS1L-MYB, and {beta}-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease PNAS, August 19, 2008; 105(33): 11869 - 11874. [Abstract] [Full Text] [PDF]

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