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Blood, 1 December 2007, Vol. 110, No. 12, pp. 3926-3935. Prepublished online as a Blood First Edition Paper on July 13, 2007; DOI 10.1182/blood-2007-01-065482.
IMMUNOBIOLOGY Rapidly induced, T-cell–independent xenoantibody production is mediated by marginal zone B cells and requires help from NK cells1 Laboratory of Experimental Transplantation and 2 Laboratory of Experimental Immunology, University of Leuven, Leuven, Belgium; 3 Bioceros, Utrecht, the Netherlands; and 4 Morphology and Molecular Pathology, University of Leuven, Leuven, Belgium
Xenoantibody production directed at a wide variety of T lymphocyte–dependent and T lymphocyte–independent xenoantigens remains the major immunologic obstacle for successful xenotransplantation. The B lymphocyte subpopulations and their helper factors, involved in T-cell–independent xenoantibody production are only partially understood, and their identification will contribute to the clinical applicability of xenotransplantation. Here we show, using models involving T-cell–deficient athymic recipient mice, that rapidly induced, T-cell–independent xenoantibody production is mediated by marginal zone B lymphocytes and requires help from natural killer (NK) cells. This collaboration neither required NK-cell–mediated IFN-
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| Copyright © 2007 by American Society of Hematology Online ISSN: 1528-0020 | |||||||||||
production, nor NK-cell–mediated cytolytic killing of xenogeneic target cells. The T-cell–independent IgM xenoantibody response could be partially suppressed by CD40L blockade. 